Joint Doctoral Program in Clinical Psychology, San Diego State University, University of California, San Diego, La Jolla, CA, USA.
Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA.
J Neurovirol. 2021 Dec;27(6):885-894. doi: 10.1007/s13365-021-01001-y. Epub 2021 Nov 4.
Older people with HIV (PWH) experience increased risk of age-related neurodegenerative disorders and cognitive decline, such as amnestic mild cognitive impairment (aMCI). The objective of this study was to examine the relationship between aMCI and plasma VEGF biomarkers among older PWH. Data were collected at a university-based research center from 2011 to 2013. Participants were 67 antiretroviral therapy-treated, virally suppressed PWH. Participants completed comprehensive neurobehavioral and neuromedical evaluations. aMCI status was determined using adapted Jak/Bondi criteria, classifying participants as aMCI + if their performance was > 1 SD below the normative mean on at least two of four memory assessments. VEGF family plasma biomarkers (i.e., VEGF, VEGF-C, VEGF-D, and PIGF) were measured by immunoassay. Logistic regression models were conducted to determine whether VEGF biomarkers were associated with aMCI status. Participants were mostly non-Hispanic white (79%) men (85%) with a mean age of 57.7 years. Eighteen (26.9%) participants met criteria for aMCI. Among potential covariates, only antidepressant drug use differed by aMCI status, and was included as a covariate. VEGF-D was significantly lower in the aMCI + group compared to the aMCI - group. No other VEGF levels (VEGF, VEGF-C, PIGF) differed by aMCI classification (ps > .05). In a sample of antiretroviral therapy-treated, virally suppressed PWH, lower levels of VEGF-D were associated with aMCI status. Longitudinal analyses in a larger and more diverse sample are needed to support VEGF-D as a putative biological marker of aMCI in HIV.
HIV 感染者（PWH）中老年人出现与年龄相关的神经退行性疾病和认知能力下降的风险增加，例如遗忘型轻度认知障碍（aMCI）。本研究的目的是探讨 aMCI 与 older PWH 血浆 VEGF 生物标志物之间的关系。数据于 2011 年至 2013 年期间在一所大学研究中心收集。参与者为 67 名接受抗逆转录病毒治疗且病毒得到抑制的 PWH。参与者完成了全面的神经行为和神经医学评估。aMCI 状态根据改编的 Jak/Bondi 标准确定，如果参与者在至少四项记忆评估中的两项上的表现低于正常平均值的 1 个标准差以上，则将其归类为 aMCI+。通过免疫测定法测量 VEGF 家族血浆生物标志物（即 VEGF、VEGF-C、VEGF-D 和 PIGF）。Logistic 回归模型用于确定 VEGF 生物标志物是否与 aMCI 状态相关。参与者主要是非西班牙裔白人（79%）男性（85%），平均年龄为 57.7 岁。18 名（26.9%）参与者符合 aMCI 标准。在潜在的协变量中，只有抗抑郁药的使用因 aMCI 状态而异，因此被纳入协变量。与 aMCI-组相比，aMCI+组的 VEGF-D 水平明显降低。其他 VEGF 水平（VEGF、VEGF-C、PIGF）的分类无差异（p>.05）。在接受抗逆转录病毒治疗且病毒得到抑制的 PWH 样本中，较低水平的 VEGF-D 与 aMCI 状态相关。需要在更大、更多样化的样本中进行纵向分析，以支持 VEGF-D 作为 HIV 中 aMCI 的潜在生物学标志物。
