Engineering Research Center of Pharmaceutical Process Chemistry, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China.
Engineering Research Center of Pharmaceutical Process Chemistry, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China.
Talanta. 2022 Jan 15;237:122964. doi: 10.1016/j.talanta.2021.122964. Epub 2021 Oct 14.
We describe a reagent-free acid-base titration method, in which only water is added and the titrant is online electrodialytically produced. Electrodialytic eluent generator, a well-established technique in ion chromatography to produce high purity base or acid eluent through precise control of an electric current, has been for the first time used for titration, termed as electrodialytic titrant generator (ETG). Three kinds of titrants produced by ETG have been demonstrated, including potassium hydroxide, methanesulfuric acid and sulfuric acid. A series of titrants with different concentration up to at least 140 mM (e.g. KOH) could be accurately and reproducibly obtained by manipulating current and the KOH titrant showed extremely high purity. The titration results achieved by ETG were in a good agreement with those obtained by the regular way and their ratio was in the range of 0.9918 and 1.0034. Good accuracy and precision were achieved for ETG titration, as indicated by 2.2% of relative error and 0.17% of relative standard error. Its utility was demonstrated to measure pKa-differentiated capacity of anion exchange resins.
我们描述了一种无需试剂的酸碱滴定方法，其中只添加水，而滴定剂则在线通过电渗析产生。电渗析洗脱液发生器是离子色谱中一种成熟的技术，通过精确控制电流来产生高纯度的碱或酸洗脱液，它首次被用于滴定，称为电渗析滴定剂发生器（ETG）。已经证明了三种由 ETG 产生的滴定剂，包括氢氧化钾、甲烷磺酸和硫酸。通过操纵电流，可以准确和重现地获得一系列浓度高达至少 140mM 的不同滴定剂（例如 KOH），并且 KOH 滴定剂具有极高的纯度。ETG 获得的滴定结果与常规方法获得的结果非常吻合，其比值在 0.9918 和 1.0034 之间。ETG 滴定具有良好的准确性和精密度，相对误差为 2.2%，相对标准误差为 0.17%。它的实用性已被证明可用于测量阴离子交换树脂的 pKa 差异容量。
