Departments of Radiology and Pediatrics (Neonatology), Children's Hospital Los Angeles, 4650 Sunset Blvd. MS #81, Los Angeles CA 90027, USA.
Department of Pediatrics (Neonatology), McGill University/Montreal Children's Hospital, Division of Newborn Medicine, Research Institute of the McGill University Health Centre, 1001 boul. Décarie, Site Glen Block E, EM0.3244, Montréal, QC H4A 3J1, Canada.
Semin Fetal Neonatal Med. 2021 Oct;26(5):101304. doi: 10.1016/j.siny.2021.101304. Epub 2021 Oct 29.
Neuroimaging is widely used to aid in the diagnosis and clinical management of neonates with neonatal encephalopathy (NE). Yet, despite widespread use clinically, there are few published guidelines on neuroimaging for neonates with NE. This review outlines the primary patterns of brain injury associated with hypoxic-ischemic injury in neonates with NE and their frequency, associated neuropathological features, and risk factors. In addition, it provides an overview of neuroimaging methods, including the most widely used scoring systems used to characterize brain injury in these neonates and their utility as predictive biomarkers. Last, recommendations for neuroimaging in neonates with NE are presented.
神经影像学广泛用于辅助新生儿脑病（NE）新生儿的诊断和临床管理。然而，尽管在临床上广泛使用，但针对 NE 新生儿的神经影像学检查几乎没有发表的指南。本综述概述了与 NE 新生儿缺氧缺血性损伤相关的主要脑损伤模式及其频率、相关神经病理学特征和危险因素。此外，它还概述了神经影像学方法，包括最常用于描述这些新生儿脑损伤的评分系统及其作为预测生物标志物的效用。最后，提出了针对 NE 新生儿的神经影像学检查建议。
