State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Nankai University, Haihe Education Park, 38 Tongyan Road, Tianjin 300353, People's Republic of China.
State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials Ministry of Education and College of Life Sciences, Nankai University, Tianjin 300071, People's Republic of China.
Adv Drug Deliv Rev. 2021 Dec;179:114028. doi: 10.1016/j.addr.2021.114028. Epub 2021 Nov 1.
The phenomenon of aggregation-induced emission (AIE) is inseparable from molecular aggregation and self-assembly. Therefore, the combination of AIE and supramolecular self-assembly is well-matched. AIE-guided dynamic assembly (AGDA) could effectively respond to the endogenous stimuli (such as pH, enzymes, redox molecules) and exogenous stimuli (temperature, light, ultrasound) in the disease microenvironment, so as to achieve specific imaging and diagnosis of the disease lesions. Moreover, AGDA also dynamically adjust the intramolecular motions of AIE molecules, thereby adjusting the energy dissipation pathways and realizing the switch between photodynamic therapy and photothermal therapy for superior therapeutic effects. In this review, we aim to give an overview of the constructing strategies, stimuli-responsive imaging, regulation of intramolecular motion of AGDA in recent years, which is expected to grasp the research status and striving directions of AGDA for imaging and therapy.
聚集诱导发光（AIE）现象与分子聚集和自组装密不可分。因此，AIE 与超分子自组装的结合非常匹配。AIE 引导的动态组装（AGDA）可以有效地响应疾病微环境中的内源性刺激（如 pH 值、酶、氧化还原分子）和外源性刺激（温度、光、超声），从而实现对疾病病变的特异性成像和诊断。此外，AGDA 还可以动态调节 AIE 分子的分子内运动，从而调节能量耗散途径，实现光动力治疗和光热治疗之间的切换，以获得更好的治疗效果。在这篇综述中，我们旨在概述近年来 AGDA 的构建策略、刺激响应成像、分子内运动调控，以期掌握 AGDA 在成像和治疗方面的研究现状和努力方向。
