Graciano-Machuca Omar, Villegas-Rivera Geannyne, López-Pérez Iván, Macías-Barragán José, Sifuentes-Franco Sonia
Laboratory of Biological Systems, Department of Health Sciences, University of Guadalajara (UDG), Ameca, Mexico.
Department of Health Sciences-Disease as an Individual Process, University of Guadalajara (UDG), Tonalá, Mexico.
Front Immunol. 2021 Oct 19;12:723654. doi: 10.3389/fimmu.2021.723654. eCollection 2021.
With the appearance of the SARS-CoV-2 virus in December 2019, all countries in the world have implemented different strategies to prevent its spread and to intensively search for effective treatments. Initially, severe cases of the disease were considered in adult patients; however, cases of older school-age children and adolescents who presented fever, hypotension, severe abdominal pain and cardiac dysfunction, positive for SARS-CoV-2 infection, have been reported, with increased pro-inflammatory cytokines and tissue damage, condition denominated multisystemic inflammatory syndrome (MIS-C); The emerging data from patients with MIS-C have suggested unique characteristics in the immunological response and also clinical similarities with other inflammatory syndromes, which can support as a reference in the search for molecular mechanisms involved in MIS-C. We here in propose that oxidative stress (OE) may play a very important role in the pathophysiology of MIS-C, such as occurs in Kawasaki disease (KD), severe COVID-19 in adults and other processes with characteristics of vascular damage similar to MIS- C, for which we review the available information that can be correlated with possible redox mechanisms.
自2019年12月严重急性呼吸综合征冠状病毒2（SARS-CoV-2）病毒出现以来，世界各国都实施了不同的策略来防止其传播，并积极寻找有效的治疗方法。最初，该疾病的重症病例被认为多见于成年患者；然而，已有报告称，一些大龄学龄儿童和青少年感染SARS-CoV-2后出现发热、低血压、严重腹痛和心脏功能障碍，且促炎细胞因子增加和组织损伤，这种情况被称为多系统炎症综合征（MIS-C）；来自MIS-C患者的新数据表明了免疫反应的独特特征，以及与其他炎症综合征的临床相似性，这可为寻找MIS-C相关分子机制提供参考。我们在此提出，氧化应激（OE）可能在MIS-C的病理生理学中起非常重要的作用，就像在川崎病（KD）、成人严重冠状病毒病2019（COVID-19）以及其他具有与MIS-C相似血管损伤特征的疾病中一样，为此我们回顾了可与可能的氧化还原机制相关的现有信息。
