Institute of Genetic Engineering, Hankyong National University, Jungang-ro, Anseong Gyeonggi-do, South Korea.
Histol Histopathol. 2022 Feb;37(2):169-180. doi: 10.14670/HH-18-393. Epub 2021 Nov 5.
Recent studies regarding the ability to relieve and reconstitute the endometrium in the treatment of endometrial cancer are limited. In this study, to analyze endometrial cancer, early endometrial cancer was induced by injecting a colon cancer cell line into the lower abdominal cavity of mice. Subsequently, the apple seed extract was administered orally to determine if the extract could affect the endometrial cancer. Administration of apple seed extract to the endometrial cancer model confirmed that the apoptosis suppressing mechanism was downregulated concurrently with the reduced expression of NF-κB. In contrast, the TNFα/p53 pathway upregulated the apoptosis. A number of clinical inferences could be derived from the results of this study; moreover, the administration of apple seed extract in a cancer metastasis model has not been reported in earlier toxicity induction studies. The results of this study indicated that the apple seed extract partially enhances apoptosis and the immune function related factors in endometrial cells. By improving tissue remodeling, the extract may help to restore the endometrium.
关于缓解和重建子宫内膜能力在子宫内膜癌治疗中的应用的研究有限。在本研究中，为了分析子宫内膜癌，通过向小鼠下腹部注射结肠癌细胞系来诱导早期子宫内膜癌。随后，口服给予苹果籽提取物，以确定提取物是否能影响子宫内膜癌。对子宫内膜癌模型给予苹果籽提取物证实，凋亡抑制机制下调，同时 NF-κB 表达减少。相反，TNFα/p53 途径上调凋亡。从这项研究的结果可以得出一些临床推论；此外，在早期毒性诱导研究中，尚未报道在癌症转移模型中给予苹果籽提取物。本研究结果表明，苹果籽提取物部分增强了子宫内膜细胞中的凋亡和与免疫功能相关的因素。通过改善组织重塑，提取物可能有助于恢复子宫内膜。
