School of Materials Science & Engineering, the Key Laboratory of Advanced Ceramics and Machining Technology by the Ministry of Education of China, Tianjin University, Weijin Avenue 92#, Tianjin 300072, China.
School of Life Science and Health Engineering, Hebei University of Technology, Xiping Avenue 5340, Beichen District, Tianjin 300401, China.
ACS Nano. 2021 Nov 23;15(11):18505-18519. doi: 10.1021/acsnano.1c08409. Epub 2021 Nov 5.
Large doses and long duration are often required for herbal medicines to kill bacteria effectively. Herein, a photoacoustic interfacial engineering strategy was utilized to endow curcumin (Cur, a kind of herbal medicine) with rapid and highly effective bacteria-killing efficacy, in which Cur was combined with CuS to form a hybrid material of CuS/Cur with tight contact through nucleation and growth on the petaloid CuS surface. Due to the different work functions of CuS and Cur, the interfacial electrons were redistributed, , a large number of electrons gathered on the side of CuS. In contrast, the holes gathered on the side of Cur after contact. An internal electric field was formed to drive the excited electrons to transfer from CuS to Cur, thus enhancing the separation of electron-hole pairs. Besides exerting the drug nature of Cur itself, the CuS/Cur hybrid also had photo-sono responsive ability, which endowed the hybrid with photothermal, photodynamic, and sonodynamic effects. Therefore, this Cur-based hybrid killed 99.56% of and 99.48% of under 808 nm near-infrared light irradiation and ultrasound successively for 15 min, which was ascribed to the synergy of ROS, hyperthermia, and released Cu together with the drug properties of Cur. This work provides a strategy to enhance the therapeutic effects of herbal medicines against pathogenic bacterial infections by exciting the intrinsic properties of herbal medicines as materials through a photo-sono interfacial engineering strategy.
中草药通常需要大剂量和长时间才能有效地杀死细菌。在此，我们利用光声界面工程策略赋予姜黄素（一种中草药）快速高效的杀菌功效，其中姜黄素与 CuS 结合，通过在花瓣状 CuS 表面成核和生长形成紧密接触的 CuS/Cur 杂化材料。由于 CuS 和姜黄素的不同功函数，界面电子重新分布，大量电子聚集在 CuS 一侧。相比之下，接触后电子聚集在姜黄素的一侧。形成内电场，驱动激发电子从 CuS 转移到姜黄素，从而增强电子-空穴对的分离。CuS/Cur 杂化物除了发挥姜黄素本身的药物性质外，还具有光声响应能力，赋予杂化物光热、光动力和超声动力效应。因此，在 808nm 近红外光照射和超声连续作用 15 分钟后，这种基于姜黄素的杂化物分别杀死了 99.56%的 和 99.48%的 ，这归因于 ROS、热疗和释放 Cu 以及姜黄素的药物性质的协同作用。这项工作通过光声界面工程策略激发中草药作为材料的固有特性，为提高中草药对抗致病菌感染的治疗效果提供了一种策略。
