Graduate Program in Basic and Applied Immunology, Federal University of Amazonas, Manaus, Amazonas, Brazil.
Post-Doctoral Fellowship in the Graduate Program of Basic and Applied Immunology, Federal University of Amazonas, Manaus, Amazonas, Brazil.
PLoS One. 2021 Nov 5;16(11):e0259545. doi: 10.1371/journal.pone.0259545. eCollection 2021.
Libidibia ferrea (Mart. ex Tul.) L. P. Queiroz (jucá) is a plant extensively used in the Brazilian folk medicine for the treatment of the inflammatory process. Primary studies have focused on the verification of these biological activities, highlighting the role of this plant in inflammatory conditions. This systematic review aimed to critically establish which part of the plant and what type of plant extract present the highest evidence of anti-inflammatory activity as in vivo and in vitro experimental models. This study has followed the recommendations by PRISMA and was registered in the PROSPERO database under number CRD42020159934. The literature review was carried out in several medical and scientific databases (Google Scholar, LILACS, ProQuest, PubMed, ScienceDirect, Scopus and Web of Science) in studies published up to February 2020 and updated on March 2021. No language restriction was made to this search. Eligibility criteria were adopted instead. The risk of bias was evaluated through SYRCLE's RoB tool for the in vivo studies. 609 studies were initiated to identify the whole and the subsequent steps of screening. 13 studies remained in the results (10 in vivo and 3 in vitro). In most studies the risk of bias was low or unclear. The high risk of bias was related to the risk of attrition and reporting bias. The fruit and the aqueous extract were identified as the most used in the studies carried out on the qualitative analysis and the results of the in vivo and in vitro studies were conducive to the anti-inflammatory action, a meta-analysis could not be performed due to heterogeneity between studies and the potential risk of bias to estimate the side effects. Therefore, the implementation of in vivo studies following the international guidelines could collaborate with analyses of the anti-inflammatory effect of jucá.
利比迪比亚 Ferrea （ Mart.exTul.） L. P. Queiroz （ jucá ）是一种广泛用于巴西民间医学治疗炎症过程的植物。初步研究集中在验证这些生物活性，强调这种植物在炎症中的作用。本系统评价旨在批判性地确定植物的哪一部分和哪种植物提取物在体内和体外实验模型中具有最高的抗炎活性证据。本研究遵循 PRISMA 的建议，并在 PROSPERO 数据库中注册，编号为 CRD42020159934 。文献综述在多个医学和科学数据库（ Google Scholar 、 LILACS 、 ProQuest 、 PubMed 、 ScienceDirect 、 Scopus 和 Web of Science ）中进行，研究对象是截至 2020 年 2 月发表的研究，并于 2021 年 3 月进行了更新。本次搜索未对语言进行限制。而是采用了合格标准。通过 SYRCLE 的 RoB 工具对体内研究进行了偏倚风险评估。为了确定整个筛选过程和后续步骤，共进行了 609 项研究。 13 项研究结果仍保留（ 10 项体内研究和 3 项体外研究）。在大多数研究中，偏倚风险较低或不明确。高偏倚风险与损耗和报告偏倚的风险有关。在定性分析中，水果和水提物被认为是最常用的，体内和体外研究的结果有利于抗炎作用，但由于研究之间存在异质性和潜在的偏倚风险来估计副作用，因此无法进行荟萃分析。因此，遵循国际指南进行体内研究可以为 jucá 的抗炎作用分析提供帮助。
