RCSB Protein Data Bank and Institute for Quantitative Biomedicine, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA; Rutgers Cancer Institute of New Jersey, Rutgers, The State University of New Jersey, New Brunswick, NJ 08903, USA; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
RCSB Protein Data Bank and Institute for Quantitative Biomedicine, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA; Rutgers Cancer Institute of New Jersey, Rutgers, The State University of New Jersey, New Brunswick, NJ 08903, USA; Research Collaboratory for Structural Bioinformatics Protein Data Bank, San Diego Supercomputer Center, University of California, San Diego, CA 92093, USA; Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.
Structure. 2022 Jan 6;30(1):55-68.e2. doi: 10.1016/j.str.2021.10.008. Epub 2021 Nov 4.
Structural biologists provide direct insights into the molecular bases of human health and disease. The open-access Protein Data Bank (PDB) stores and delivers three-dimensional (3D) biostructure data that facilitate discovery and development of therapeutic agents and diagnostic tools. We are in the midst of a revolution in vaccinology. Non-infectious mRNA vaccines have been proven during the coronavirus disease 2019 (COVID-19) pandemic. This new technology underpins nimble discovery and clinical development platforms that use knowledge of 3D viral protein structures for societal benefit. The RCSB PDB supports vaccine designers through expert biocuration and rigorous validation of 3D structures; open-access dissemination of structure information; and search, visualization, and analysis tools for structure-guided design efforts. This resource article examines the structural biology underpinning the success of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) mRNA vaccines and enumerates some of the many protein structures in the PDB archive that could guide design of new countermeasures against existing and emerging viral pathogens.
结构生物学家为人类健康和疾病的分子基础提供了直接的见解。开放获取的蛋白质数据库 (PDB) 存储和提供三维 (3D) 生物结构数据，促进了治疗剂和诊断工具的发现和开发。我们正处在疫苗学革命之中。在 2019 年冠状病毒病 (COVID-19) 大流行期间，非传染性的 mRNA 疫苗已被证明有效。这项新技术为灵活的发现和临床开发平台提供了支持，这些平台利用 3D 病毒蛋白结构的知识造福社会。RCSB PDB 通过对 3D 结构进行专业的生物信息学注释和严格的验证、开放获取的结构信息传播以及用于结构指导设计工作的搜索、可视化和分析工具，为疫苗设计师提供支持。这篇资源文章探讨了严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) mRNA 疫苗成功背后的结构生物学，并列举了 PDB 档案中可能指导针对现有和新出现的病毒病原体设计新对策的许多蛋白质结构。
