State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops, Key Lab of Biopesticide and Chemical Biology, Ministry of Education & Fujian Province Key Laboratory of Insect Ecology, College of Plant Protection, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, PR China.
College of Plant Protection, Key Laboratory of Pesticide Toxicology & Application Technique, Shandong Agricultural University, Tai'an, Shandong 271018, PR China.
Colloids Surf B Biointerfaces. 2022 Jan;209(Pt 1):112166. doi: 10.1016/j.colsurfb.2021.112166. Epub 2021 Oct 20.
To reduce the negative impact of nanopesticide carriers of on the environment, a greener nanodelivery system is necessary. Nanogels are nontoxic and degradable carriers, however, the potential of nanogels for delivering pesticides has not been proven. In this study, poly(vinyl alcohol)-valine, an ecofriendly polymer, was synthesized and used to fabricate emamectin benzoate nanogel suspension (EB NS). The nanoformulation showed favorable stability at low temperature, high temperature or one year storage, and in water with different hardnesses. The retention of the EB NS solution on leaves was higher than that of an EB emulsifiable concentrate (EC) by approximately 9% at a concentration of 10 mg L. The half-life of EB nanogels under Ultra Violet irradiation was prolonged by 3.3-fold. Moreover, the bioactivity of the EB NS against Plutella xylostella was higher than that of the EB EC. These advantages resulted in a relatively long duration of pest control. The response of nanogels to laccase, a digestive enzyme in the digestive tract of lepidopteran pests, enables pesticide release on demand. Nanogels have the advantages of being ecofriendly carriers, exhibiting higher utilization, and prolonged pest control periods, and they have a brilliant future in pesticide delivery.
为了降低纳米农药载体对环境的负面影响，有必要开发更绿色的纳米递药系统。纳米凝胶作为一种无毒、可降解的载体，但其作为农药载体的潜力尚未得到证实。本研究合成了一种环境友好型聚合物聚（聚乙烯醇）-缬氨酸，并用于制备甲氨基阿维菌素苯甲酸盐纳米凝胶悬浮剂（EB NS）。该纳米制剂在低温、高温或一年的储存期以及不同硬度的水中均表现出良好的稳定性。在 10mg/L 的浓度下，EB NS 溶液在叶片上的保留率比 EB 乳油（EC）高约 9%。紫外辐射下 EB 纳米凝胶的半衰期延长了 3.3 倍。此外，EB NS 对小菜蛾的生物活性高于 EB EC。这些优势导致了相对较长的害虫防治期。纳米凝胶对漆酶（鳞翅目害虫消化道中的一种消化酶）的响应使得农药能够按需释放。纳米凝胶作为环境友好型载体具有较高的利用率和延长的害虫防治期的优势，在农药递送方面具有广阔的前景。
