Liu Zihe, Wang Junyang, Nielsen Jens
College of Life Science and Technology, Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, 100029 Beijing, China.
College of Life Science and Technology, Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, 100029 Beijing, China; Department of Biology and Biological Engineering, Chalmers University of Technology, SE412 96 Gothenburg, Sweden; BioInnovation Institute, Ole Maaløes Vej 3, DK2200 Copenhagen N, Denmark.
Curr Opin Microbiol. 2022 Feb;65:33-39. doi: 10.1016/j.mib.2021.10.010. Epub 2021 Oct 29.
Increasing concerns of environmental impacts and global warming calls for urgent need to switch from use of fossil fuels to renewable technologies. Biofuels represent attractive alternatives of fossil fuels and have gained continuous attentions. Through the use of synthetic biology it has become possible to engineer microbial cell factories for efficient biofuel production in a more precise and efficient manner. Here, we review advances on yeast-based biofuel production. Following an overview of synthetic biology impacts on biofuel production, we review recent advancements on the design, build, test, learn steps of yeast-based biofuel production, and end with discussion of challenges associated with use of synthetic biology for developing novel processes for biofuel production.
对环境影响和全球变暖的日益关注，迫切需要从使用化石燃料转向可再生技术。生物燃料是化石燃料颇具吸引力的替代品，并一直受到持续关注。通过合成生物学的应用，已经能够以更精确、高效的方式设计微生物细胞工厂以实现高效生物燃料生产。在此，我们综述基于酵母的生物燃料生产的进展。在概述合成生物学对生物燃料生产的影响之后，我们综述基于酵母的生物燃料生产在设计、构建、测试、学习步骤方面的最新进展，并最后讨论与利用合成生物学开发新型生物燃料生产工艺相关的挑战。
