Scholtz Alexis, Ramoji Anuradha, Silge Anja, Jansson Jakob R, de Moura Ian G, Popp Jürgen, Sram Jakub P, Armani Andrea M
Department of Biomedical Engineering, University of Southern California, Los Angeles, California 90089, United States of America.
Institute of Physical Chemistry (IPC) and Abbe Center of Photonics, Helmholtzweg 4, 07743 Jena, Germany.
ACS Photonics. 2021 Sep 15;8(10):2827-2838. doi: 10.1021/acsphotonics.1c01052. eCollection 2021 Oct 20.
In winter of 2020, SARS-CoV-2 emerged as a global threat, impacting not only health but also financial and political stability. To address the societal need for monitoring the spread of SARS-CoV-2, many existing diagnostic technologies were quickly adapted to detect SARS-CoV-2 RNA and antigens as well as the immune response, and new testing strategies were developed to accelerate time-to-decision. In parallel, the infusion of research support accelerated the development of new spectroscopic methods. While these methods have significantly reduced the impact of SARS-CoV-2 on society when coupled with behavioral changes, they also lay the groundwork for a new generation of platform technologies. With several epidemics on the horizon, such as the rise of antibiotic-resistant bacteria, the ability to quickly pivot the target pathogen of this diagnostic toolset will continue to have an impact.
2020年冬季，严重急性呼吸综合征冠状病毒2（SARS-CoV-2）成为全球威胁，不仅影响健康，还影响金融和政治稳定。为满足社会监测SARS-CoV-2传播的需求，许多现有诊断技术迅速调整，以检测SARS-CoV-2 RNA、抗原以及免疫反应，并开发了新的检测策略以加快决策时间。与此同时，研究支持的注入加速了新光谱方法的开发。虽然这些方法与行为改变相结合时显著降低了SARS-CoV-2对社会的影响，但它们也为新一代平台技术奠定了基础。鉴于未来还会出现几种流行病，比如耐药细菌的增加，快速调整这种诊断工具集的目标病原体的能力将继续产生影响。
