具有抗菌活性的自修复多糖基可注射水凝胶用于伤口愈合。
Self-healing polysaccharide-based injectable hydrogels with antibacterial activity for wound healing.
机构信息
College of Chemical Engineering, Huaqiao University, Xiamen 361021, China; Xiamen Engineering and Technological Research Center for Comprehensive Utilization of Marine Biological Resources, Xiamen 361021, China.
College of Chemical Engineering, Huaqiao University, Xiamen 361021, China; Xiamen Engineering and Technological Research Center for Comprehensive Utilization of Marine Biological Resources, Xiamen 361021, China.
出版信息
Carbohydr Polym. 2022 Jan 1;275:118770. doi: 10.1016/j.carbpol.2021.118770. Epub 2021 Oct 17.
Because the wound is difficult to heal, repeated bacterial infection will lead to complex clinical problems. Therefore, it is necessary to find an effective method to strengthen the healing process and resist bacterial infection. Hydrogels have many advantages, such as injectability and self-healing under physiological conditions, so they have been widely studied in recent years. Hydrogels can keep the wound moist and promote the wound healing. In addition, the growth of bacteria can be obviously inhibited by hydrogels themself or by doping some antibacterial active substances. Based on this, herein, this review highlighted the preparation and properties of different polysaccharide-based injectable hydrogels, and discuss their biological applications in antibacterial therapy for wound healing in recent years.
由于伤口难以愈合，反复的细菌感染会导致复杂的临床问题。因此，有必要寻找一种有效的方法来加强愈合过程并抵抗细菌感染。水凝胶具有许多优点，例如在生理条件下可注射和自修复，因此近年来受到了广泛的研究。水凝胶可以保持伤口湿润，促进伤口愈合。此外，水凝胶本身或掺杂一些抗菌活性物质可以明显抑制细菌的生长。基于此，本文重点介绍了不同多糖基可注射水凝胶的制备和性能，并讨论了它们在近年来抗菌治疗促进伤口愈合方面的生物应用。
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