Department of Neonatology, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.
Department of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Front Immunol. 2021 Oct 20;12:765994. doi: 10.3389/fimmu.2021.765994. eCollection 2021.
Bone metastasis is commonly seen in patients with breast cancer, prostate cancer and lung cancer. Tumor-intrinsic factors and the tumor microenvironment cooperate to affect the formation of bone metastatic niche. Within the bone microenvironment, immune cells have been regarded as a major contributor to metastatic progression. In this review, we describe the dynamic roles of immune cells in regulating metastatic homing, seeding, dormancy, and outgrowth in the bone. We also summarize the diverse functions of immune molecules including chemokines, cytokines, and exosomes in remodeling the bone metastatic niche. Furthermore, we discuss the therapeutic and prognostic potential of these cellular and molecular players in bone metastasis.
骨转移在乳腺癌、前列腺癌和肺癌患者中很常见。肿瘤内在因素和肿瘤微环境共同作用影响骨转移龛的形成。在骨微环境中，免疫细胞被认为是促进转移进展的主要因素。在这篇综述中，我们描述了免疫细胞在调节转移灶归巢、播种、休眠和在骨中生长中的动态作用。我们还总结了免疫分子（包括趋化因子、细胞因子和外泌体）在重塑骨转移龛中的多种功能。此外，我们还讨论了这些细胞和分子在骨转移中的治疗和预后潜力。
