血清 25-羟维生素 D 水平与卒中风险的相关性研究：基于全国健康与营养调查的分析。
Association between Serum 25-Hydroxyvitamin D Level and Stroke Risk: An Analysis Based on the National Health and Nutrition Examination Survey.
机构信息
School of Nursing, Tianjin Medical University, Tianjin 300070, China.
School of Public Health, Tianjin Medical University, Tianjin 300070, China.
出版信息
Behav Neurol. 2021 Oct 29;2021:5457881. doi: 10.1155/2021/5457881. eCollection 2021.
BACKGROUND
To analyze the association between serum 25-hydroxyvitamin D level (25(OH)D) and stroke risk based on the National Health and Nutrition Examination Survey (NHANES).
METHODS
Between 2007 and 2018, the baseline information of participants from NHNES was collected. Univariate analysis was used to identify the covariates. Multivariate logistic regression model was used to analyze the association between serum 25(OH)D level and the stroke risk.
RESULTS
Of the 8,523 participants, there were 310 participants with stroke and 8,213 participants without stroke. The multivariate logistic analysis showed that serum 25(OH)D deficiency (odds ratio (OR): 1.993, 95% confidence intervals (CI): 1.141-3.481, and = 0.012) was the significant risk factors for stroke. Subgroup analysis showed that non-Hispanic whites with serum 25(OH)D deficiency (OR: 2.501, 95% CI: 1.094-5.720, and = 0.001) and insufficiency (OR: 1.853, 95% CI: 1.170-2.934, and = 0.006) were associated with a higher risk of stroke than those with normal 25(OH)D levels.
CONCLUSIONS
Serum 25(OH)D deficiency may be associated with an increased risk of stroke.
背景
基于国家健康和营养检查调查（NHANES）分析血清 25-羟维生素 D 水平（25（OH）D）与中风风险之间的关系。
方法
在 2007 年至 2018 年期间，收集了来自 NHANES 的参与者的基线信息。使用单变量分析来确定协变量。使用多变量逻辑回归模型分析血清 25（OH）D 水平与中风风险之间的关系。
结果
在 8523 名参与者中，有 310 名参与者患有中风，8213 名参与者没有中风。多变量逻辑分析显示，血清 25（OH）D 缺乏（比值比（OR）：1.993，95％置信区间（CI）：1.141-3.481， = 0.012）是中风的显著危险因素。亚组分析表明，非西班牙裔白种人血清 25（OH）D 缺乏（OR：2.501，95％CI：1.094-5.720， = 0.001）和不足（OR：1.853，95％CI：1.170-2.934， = 0.006）与中风风险升高相关，与正常 25（OH）D 水平相比。
结论
血清 25（OH）D 缺乏可能与中风风险增加有关。
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