Ahmadipour Sanaz, Field Robert A, Miller Gavin J
Department of Chemistry and Manchester Institute of Biotechnology, The University of Manchester, Manchester M1 7DN, United Kingdom.
Iceni Diagnostics Ltd, The Innovation Centre, Norwich Research Park, Norwich, Norfolk NR4 7GJ, United Kingdom.
Cell Surf. 2021 Oct 16;7:100063. doi: 10.1016/j.tcsw.2021.100063. eCollection 2021 Dec.
The impact of fungal infections on humans is a serious public health issue that has received much less attention than bacterial infection and treatment, despite ever-increasing incidence exacerbated by an increased incidence of immunocompromised individuals in the population. species, in particular, cause some of the most prevalent hospital-related fungal infections. Fungal infections are also detrimental to the well-being of grazing livestock, with milk production in dairy cows, and body and coat condition adversely affected by fungal infections. Fungal cell walls are essential for viability, morphogenesis and pathogenesis: numerous anti-fungal drugs rely on targeting either the cell wall or cell membrane, but the pipeline of available bioactives is limited. There is a clear and unmet need to identify novel targets and develop new classes of anti-fungal agents. This mini review focuses on fungal cell wall structure, composition and biosynthesis in spp., including . In addition, an overview of current advances in the development of cell wall targeted therapies is considered.
真菌感染对人类的影响是一个严重的公共卫生问题，尽管免疫功能低下个体在人群中的发病率增加导致真菌感染的发病率不断上升，但与细菌感染及治疗相比，它受到的关注要少得多。某些真菌物种尤其会引发一些最常见的医院相关真菌感染。真菌感染对放牧牲畜的健康也有害，奶牛的产奶量以及身体状况和皮毛状况都会受到真菌感染的不利影响。真菌细胞壁对于生存能力、形态发生和发病机制至关重要：许多抗真菌药物依赖于靶向细胞壁或细胞膜，但可用生物活性物质的渠道有限。明确且未得到满足的需求是识别新的靶点并开发新型抗真菌药物。本综述聚焦于特定真菌物种（包括……）的真菌细胞壁结构、组成和生物合成。此外，还探讨了细胞壁靶向疗法开发的当前进展概况。
