Vejerslev L O, Fisher R A, Surti U, Walke N
Am J Obstet Gynecol. 1987 Jul;157(1):180-4. doi: 10.1016/s0002-9378(87)80376-9.
Unusual observations in hydatidiform moles are of clinical importance as well as of theoretical interest when the present subgrouping into partial or complete moles is evaluated, particularly in view of the more malignant potential of the latter. The purpose of the present review is to summarize, update, and evaluate information on moles with unusual karyotypes or origins. The important factor in the evolution of partial or complete moles appears to be the ratio of maternal to paternal chromosomes and not the ploidy of the tissue. Complete hydatidiform moles develop from androgenetic conceptions while partial hydatidiform moles develop from those conceptions in which the number of paternal sets of chromosomes exceeds the number of maternally derived sets. Rare cases inconsistent with this concept emphasize the value of examining morphologic features, cell ploidy, and genetic markers when one is attempting to classify hydatidiform moles.
当对目前将葡萄胎分为部分性或完全性葡萄胎的亚组进行评估时，葡萄胎中的异常观察结果不仅具有理论意义，还具有临床重要性，特别是考虑到后者具有更高的恶变潜能。本综述的目的是总结、更新和评估有关具有异常核型或起源的葡萄胎的信息。部分性或完全性葡萄胎演变的重要因素似乎是母源染色体与父源染色体的比例，而非组织的倍性。完全性葡萄胎由孤雄生殖概念发展而来，而部分性葡萄胎则由父源染色体组数超过母源染色体组数的那些概念发展而来。与这一概念不符的罕见病例强调了在试图对葡萄胎进行分类时检查形态学特征、细胞倍性和遗传标记的价值。
