Peirano Gisele, Matsumara Yasufumi, Nobrega Diego, DeVinney Rebekah, Pitout Johann
Alberta Precision Laboratories, Calgary, Alberta, Canada.
Cummings School of Medicine, University of Calgary, #9, 3535 Research Road NW, Calgary, Alberta, T2L 2K8, Canada.
Eur J Clin Microbiol Infect Dis. 2021 Nov 9. doi: 10.1007/s10096-021-04373-5.
Escherichia coli ST1193 is an emerging global clone associated with fluoroquinolone resistance. A population-based study described genomics, clinical factors, susceptibility patterns, and incidence rates of ST1193 (n = 69) causing incident blood stream infections in a centralized Canadian region 2016-18. ST1193 was responsible for community-acquired upper urinary tract infections among the elderly. The incidence rate (IR) per 100,000 person-years among Calgary residents increased from 1.0 (95%confidence interval [95%CI] 0.7-1.5) in 2016, to 1.7 (95%CI 1.3-2.3) in 2018 (p = 0.05). This was mainly due to the significant increase of ST1193 blood stream infections among female long-term care (LTC) residents. ST1193 IR with bla was 3.18 times higher in 2018 than in 2016 (CI 95% 0.98-13.49). We identified a ST1193 isolate with only a parC S80I mutation that is different from previously published data. The population-based study identified a significant increase over a 2-year period of E. coli ST1193 blood stream infections among elderly females residing in LTC centers. There was also a notable increase of ST1193 with bla in 2018. The rapid emergence of ST1193 is concerning and adding to the public health burden of multidrug resistant E. coli blood stream infections in Calgary.
大肠杆菌ST1193是一种新出现的与氟喹诺酮耐药性相关的全球克隆菌株。一项基于人群的研究描述了2016 - 2018年在加拿大一个集中地区导致新发血流感染的ST1193（n = 69）的基因组学、临床因素、药敏模式和发病率。ST1193是老年人社区获得性上尿路感染的病因。卡尔加里居民每10万人年的发病率从2016年的1.0（95%置信区间[95%CI] 0.7 - 1.5）增至2018年的1.7（95%CI 1.3 - 2.3）（p = 0.05）。这主要是由于女性长期护理（LTC）机构居民中ST1193血流感染显著增加。2018年携带bla的ST1193发病率比2016年高3.18倍（95%CI 0.98 - 13.49）。我们鉴定出一株仅携带parC S80I突变的ST1193分离株，这与先前发表的数据不同。这项基于人群的研究发现，在两年时间里，居住在LTC中心的老年女性中大肠杆菌ST1193血流感染显著增加。2018年携带bla的ST1193也显著增加。ST1193的迅速出现令人担忧，并加重了卡尔加里耐多药大肠杆菌血流感染的公共卫生负担。
