Zakut-Houri R, Hazum S, Givol D, Telerman A
Gene. 1987;54(1):105-11. doi: 10.1016/0378-1119(87)90352-0.
The putative oncogene pim-1 is frequently activated by provirus insertion in MuLV-induced T cell lymphomas in mice. By analogy with other cellular oncogenes that are similarly activated (e.g., myc, myb, erbB) it is possible that pim-1 may also be involved in some human tumors. To study human pim-1 we cloned and sequenced human pim-1 cDNA clones. The human pim-1 codes for a protein of 313 amino acids (aa) which is highly homologous (94%) to the deduced amino acid sequence of mouse pim-1. All the mouse pim-1 residues which are homologous to protein kinases are conserved in the human pim-1. We also isolated the human pim-1 gene and mapped it relative to the cDNA. The RNA transcript of human pim-1 is approx. 3.0 kb and it is highly expressed in the erythroleukemia cell line K562.
假定的癌基因pim-1在小鼠MuLV诱导的T细胞淋巴瘤中常因前病毒插入而被激活。与其他类似被激活的细胞癌基因（如myc、myb、erbB）类似，pim-1也有可能参与某些人类肿瘤的发生。为了研究人类pim-1，我们克隆并测序了人类pim-1 cDNA克隆。人类pim-1编码一种由313个氨基酸（aa）组成的蛋白质，它与小鼠pim-1的推导氨基酸序列高度同源（94%）。所有与蛋白激酶同源的小鼠pim-1残基在人类pim-1中都保守存在。我们还分离出了人类pim-1基因，并将其相对于cDNA进行了定位。人类pim-1的RNA转录本约为3.0 kb，在红白血病细胞系K562中高表达。
