Wilson J F, Cantor M B
J Exp Anal Behav. 1987 May;47(3):335-46. doi: 10.1901/jeab.1987.47-335.
Nineteen rats were maintained throughout the experiment on ad libitum wet mash and water and were trained to press a lever on fixed-interval or fixed-ratio schedules of reinforcement with electrical brain stimulation. Fourteen rats ate at least 150% more mash during intermittent reinforcement sessions than during baseline, massed reinforcement control, and/or extinction sessions. In a 3-hr session, 11 of those 14 consumed more than 22 g of wet mash (13 g dry weight), the equivalent of nearly half an animal's daily food intake. In subsequent control sessions, the electrodes did not support stimulus-bound eating despite attempts to make stimulation parameters optimal. These results indicate that the eating was schedule induced or adjunctive, and suggest that the procedure may provide an animal model of excessive nonregulatory eating that contributes to obesity in humans.
在整个实验过程中，19只大鼠自由摄取湿饲料和水，并接受训练，通过脑电刺激在固定间隔或固定比率强化程序下按压杠杆。14只大鼠在间歇性强化训练期间比在基线、集中强化对照和/或消退训练期间多吃至少150%的湿饲料。在3小时的训练中，这14只大鼠中有11只消耗了超过22克的湿饲料（13克干重），几乎相当于一只动物每日食物摄入量的一半。在随后的对照训练中，尽管试图使刺激参数达到最佳，但电极并未引发受刺激约束的进食行为。这些结果表明，进食是由程序诱导或辅助性的，并表明该程序可能提供一种非调节性过度进食的动物模型，这种过度进食会导致人类肥胖。
