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血小板中的信息:解析骨髓增殖性肿瘤中的血小板转录组。

Message in a platelet: decoding platelet transcriptomes in myeloproliferative neoplasms.

机构信息

Oxford University Hospitals NHS Foundation Trust, Oxford NIHR Biomedical Research Centre, Oxford, UK.

MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine and National Institutes for Health Research Biomedical Research Centre, University of Oxford, Oxford, UK.

出版信息

Cell Rep Med. 2021 Oct 19;2(10):100433. doi: 10.1016/j.xcrm.2021.100433.

DOI:10.1016/j.xcrm.2021.100433
PMID:34755142
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8561304/
Abstract

Platelets are anucleate but contain a rich repertoire of mRNAs. In this issue of , Shen and colleagues present platelet transcriptomes from patients with myeloproliferative neoplasms to study disease mechanisms and generate a predictive algorithm for fibrotic progression.

摘要

血小板无核,但含有丰富的 mRNA 谱。在本期的 中,Shen 及其同事展示了来自骨髓增殖性肿瘤患者的血小板转录组,以研究疾病机制并生成纤维化进展的预测算法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d7fa/8561304/9bf97b3b2441/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d7fa/8561304/9bf97b3b2441/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d7fa/8561304/9bf97b3b2441/gr1.jpg

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本文引用的文献

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Cell Rep Med. 2021 Oct 19;2(10):100425. doi: 10.1016/j.xcrm.2021.100425.
2
Transcriptomic landscape of blood platelets in healthy donors.健康供者血小板的转录组图谱。
Sci Rep. 2021 Aug 3;11(1):15679. doi: 10.1038/s41598-021-94003-z.
3
Myeloproliferative neoplasms: from origins to outcomes.骨髓增殖性肿瘤:从起源到结局。
Blood. 2017 Dec 7;130(23):2475-2483. doi: 10.1182/blood-2017-06-782037.
4
Swarm Intelligence-Enhanced Detection of Non-Small-Cell Lung Cancer Using Tumor-Educated Platelets.基于肿瘤驯化血小板的群体智能增强型非小细胞肺癌检测
Cancer Cell. 2017 Aug 14;32(2):238-252.e9. doi: 10.1016/j.ccell.2017.07.004.
5
After 10years of JAK2V617F: Disease biology and current management strategies in polycythaemia vera.JAK2V617F发现10年后:真性红细胞增多症的疾病生物学与当前管理策略
Blood Rev. 2017 May;31(3):101-118. doi: 10.1016/j.blre.2016.11.001. Epub 2016 Nov 15.
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Blood-Derived Extracellular RNA and Platelet Pathobiology: Adding Pieces to a Complex Circulating Puzzle.血液来源的细胞外RNA与血小板病理生物学:为复杂的循环难题添砖加瓦
Circ Res. 2016 Feb 5;118(3):374-6. doi: 10.1161/CIRCRESAHA.115.308190.
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Blood. 2014 Jul 24;124(4):493-502. doi: 10.1182/blood-2014-04-512756. Epub 2014 Jun 5.
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