Charpié M A, Piffaretti J C, Pitton J S
Schweiz Med Wochenschr. 1978 May 13;108(19):701-8.
Resistance factors are small independent extrachromosomal DNA molecules (plasmids) conferring resistance on one or more antibiotics to the bacteria which harbour them; in Enterobacteriaceae and other gramnegative bacteria they are transferable by conjugation. The work is reviewed which has been undertaken to underline the importance of the R factors in nature, and more precisely in the current environment of the intestinal bacteria (animal and human gut, sewage) under the selective pressure of antibiotics or otherwise.
耐药因子是小型独立的染色体外DNA分子（质粒），能使携带它们的细菌对一种或多种抗生素产生耐药性；在肠杆菌科细菌和其他革兰氏阴性菌中，它们可通过接合作用进行转移。本文综述了相关研究工作，这些工作旨在强调耐药因子在自然界中的重要性，更确切地说是在抗生素或其他选择压力下，肠道细菌（动物和人类肠道、污水）当前环境中的重要性。
