Pan Dayu, Liu Weixiao, Zhu Shibo, Fan Baoyou, Yu Nanxi, Ning Guangzhi, Feng Shiqing
Department of Orthopedics, Tianjin Medical University General Hospital, Heping District, Tianjin, 300052, PR China.
Tianjin Neurological Institute, Key Laboratory of Post-Neuro Injury Neuro-repair and Regeneration in Central Nervous System, Ministry of Education and Tianjin City, Heping District, Tianjin, 300052, PR China.
J Orthop Translat. 2021 Oct 25;31:33-40. doi: 10.1016/j.jot.2021.09.008. eCollection 2021 Nov.
Spinal cord injury (SCI) is a disastrous situation that affects many patients worldwide. A profound understanding of the pathology and etiology of SCI is of great importance in inspiring new therapeutic concepts and treatment. In recent years, exosomes, which are complex lipid membrane structures secreted nearly by all kinds of plants and animal cells, can transport their valuable cargoes (e.g., proteins, lipids, RNAs) to the targeted cells and exert their communication and regulation functions, which open up a new field of treatment of SCI. Notably, the exosome's advantage is transporting the carried material to the target cells across the blood-brain barrier and exerting regulatory functions. Among the cargoes of exosomes, microRNAs, through the modulation of their mRNA targets, emerges with great potentiality in the pathological process, diagnosis and treatment of SCI. In this review, we discuss the role of miRNAs transported by different cell-derived exosomes in SCI that are poised to enhance SCI-specific therapeutic capabilities of exosomes.
脊髓损伤（SCI）是一种灾难性状况，影响着全球众多患者。深入了解SCI的病理学和病因对于激发新的治疗理念和治疗方法至关重要。近年来，外泌体作为几乎由各种动植物细胞分泌的复杂脂质膜结构，能够将其有价值的货物（如蛋白质、脂质、RNA）转运至靶细胞并发挥其通讯和调节功能，这为SCI的治疗开辟了一个新领域。值得注意的是，外泌体的优势在于能够跨越血脑屏障将携带的物质转运至靶细胞并发挥调节功能。在外泌体的货物中，微小RNA通过对其mRNA靶标的调控，在SCI的病理过程、诊断和治疗中展现出巨大潜力。在本综述中，我们讨论了不同细胞来源的外泌体所转运的miRNA在SCI中的作用，这些作用有望增强外泌体针对SCI的治疗能力。
