Rheumatology Unit, University of Verona, Pz Scuro 10, 37134, Verona, Italy.
Italian Institute for Environmental Protection and Research, Rome, Italy.
Osteoporos Int. 2022 Jan;33(1):169-176. doi: 10.1007/s00198-021-06060-9. Epub 2021 Jul 15.
Long-term environmental air pollution exposure was associated with osteoporosis' risk in a cohort of women at high risk of fracture. Cortical sites seemed to be more susceptible to the exposure's effect.
Environmental air pollution has been associated with disruption of bone health at a molecular level. Particulate matter (PM) exposure can simultaneously stimulate bone resorption and halt bone formation. The primary aim of the present study is to describe the association between long-term exposure to PM and osteoporosis in a large cohort of women at high risk of fracture.
Clinical, demographic, and densitometric data were extracted from the DeFRAcalc79 dataset, which gathers data on women at risk for osteoporosis. Data on the monitoring of PM10 and PM2.5 concentrations were retrieved from the Italian institute of environment protection and research (Istituto Superiore per la Protezione e la Ricerca Ambientale, ISPRA). Generalized linear models with robust estimators were employed to determine the relationship between BMD and PM long-term exposure.
A total 59,950 women from 110 Italian provinces were included in the study. PM 2.5 exposure was negatively associated with T-score levels at the femoral neck (β -0.005, 95 CI -0.007 to -0.003) and lumbar spine (β -0.003, 95% CI -0.006 to -0.001). Chronic exposure to PM2.5 above 25 μg/m was associated with a 16% higher risk of having osteoporotic T-score at any site (aOR 1.161, 95% CI 1.105 to 1.220), and exposure to PM10 above 30 μg/m was associated with a 15% higher risk of having osteoporotic T-score at any site (aOR 1.148, 95% CI 1.098 to 1.200).
Long-term exposure to air pollution was associated with higher risk of osteoporosis. Femoral neck site seemed to be more susceptible to the detrimental effect of PM exposure than lumbar spine site.
Exposure to air pollution is associated with osteoporosis, mainly at femoral site.
描述长期暴露于 PM 与骨质疏松症在高骨折风险的大型女性队列中的关联。
从 DeFRAcalc79 数据集提取临床、人口统计学和骨密度数据，该数据集收集了骨质疏松症高危女性的数据。从意大利环境保护和研究研究所 (Istituto Superiore per la Protezione e la Ricerca Ambientale, ISPRA) 获取 PM10 和 PM2.5 浓度监测数据。使用稳健估计的广义线性模型来确定 BMD 与 PM 长期暴露之间的关系。
研究纳入了来自意大利 110 个省的 59950 名女性。PM2.5 暴露与股骨颈 (β-0.005，95%CI-0.007 至-0.003) 和腰椎 (β-0.003，95%CI-0.006 至-0.001) 的 T 评分水平呈负相关。慢性暴露于 PM2.5 超过 25μg/m 与任何部位发生骨质疏松性 T 评分的风险增加 16%相关 (aOR 1.161，95%CI 1.105 至 1.220)，暴露于 PM10 超过 30μg/m 与任何部位发生骨质疏松性 T 评分的风险增加 15%相关 (aOR 1.148，95%CI 1.098 至 1.200)。
长期暴露于空气污染与骨质疏松症风险增加相关。与腰椎相比，股骨颈部位似乎更容易受到 PM 暴露的有害影响。
空气污染暴露与骨质疏松症相关，主要发生在股骨部位。
