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金雀异黄素和运动疗法降低了喂食高脂高果糖饮食的去卵巢大鼠中与非酒精性脂肪性肝炎相关的组蛋白去乙酰化酶3、白细胞介素-13和基质金属蛋白酶12的表达。

Genistein and exercise treatment reduced NASH related HDAC3, IL-13 and MMP-12 expressions in ovariectomized rats fed with high fat high fructose diet.

作者信息

Witayavanitkul Namthip, Werawatganon Duangporn, Chayanupatkul Maneerat, Klaikeaw Naruemon, Siriviriyakul Prasong

机构信息

Alternative and Complementary Medicine for Gastrointestinal and Liver Diseases Research Unit, Department of Physiology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.

Department of Pathology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.

出版信息

J Tradit Complement Med. 2021 May 3;11(6):503-512. doi: 10.1016/j.jtcme.2021.04.004. eCollection 2021 Nov.

DOI:10.1016/j.jtcme.2021.04.004
PMID:34765514
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8572705/
Abstract

BACKGROUND AND AIM: Genistein (GEN) and exercise (Ex) may be regarded as an alternative treatment for non-alcoholic steatohepatitis (NASH). However, the mechanisms behind their therapeutic effects in NASH are not well-understood. EXPERIMENTAL PROCEDURE: This study investigated the roles of histone deacetylase (HDAC)3 and interleukin-(IL-)13 in the NASH model of ovariectomized (OVX) rats fed with high fat high fructose (HFHF) diet. RESULTS AND CONCLUSION: Nine weeks after being fed with HFHF diet, severe NASH pathology with mild fibrosis were seen along with an increase in HDAC3, IL-13 and matrix metalloelastase (MMP-12) expressions in OVX rats. Five weeks of either GEN or Ex treatments abrogated the increase in both HDAC3 and IL-13 expressions in OVX rats fed with HFHF diet and ameliorated NASH features, liver fibrosis and MMP-12 expression. The combination of Gen and Ex, however, did not provide additional benefits on NASH features in OVX rats fed with HFHF diet. These results suggested that GEN and Ex treatments improved HFHF diet induced NASH in OVX rats through the suppression of HDAC3, IL-13 and MMP-12 expression.

摘要

背景与目的：染料木黄酮（GEN）和运动（Ex）可能被视为非酒精性脂肪性肝炎（NASH）的一种替代治疗方法。然而，它们在NASH中的治疗作用背后的机制尚不清楚。 实验步骤：本研究调查了组蛋白去乙酰化酶（HDAC）3和白细胞介素-（IL-）13在喂食高脂肪高果糖（HFHF）饮食的去卵巢（OVX）大鼠的NASH模型中的作用。 结果与结论：在喂食HFHF饮食9周后，OVX大鼠出现严重的NASH病理改变并伴有轻度纤维化，同时HDAC3、IL-13和基质金属弹性蛋白酶（MMP-12）表达增加。GEN或Ex处理5周消除了喂食HFHF饮食的OVX大鼠中HDAC3和IL-13表达的增加，并改善了NASH特征、肝纤维化和MMP-12表达。然而，GEN和Ex的联合应用并未给喂食HFHF饮食的OVX大鼠的NASH特征带来额外益处。这些结果表明，GEN和Ex处理通过抑制HDAC3、IL-13和MMP-12表达改善了HFHF饮食诱导的OVX大鼠的NASH。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5013/8572705/b13e5aa827a9/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5013/8572705/d71763d1a818/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5013/8572705/58d718c625d3/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5013/8572705/8ddabf547541/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5013/8572705/1641feb8b8c1/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5013/8572705/4446c28988b8/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5013/8572705/ad1484027da6/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5013/8572705/b13e5aa827a9/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5013/8572705/d71763d1a818/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5013/8572705/58d718c625d3/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5013/8572705/8ddabf547541/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5013/8572705/1641feb8b8c1/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5013/8572705/4446c28988b8/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5013/8572705/ad1484027da6/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5013/8572705/b13e5aa827a9/gr6.jpg

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[2]
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[3]
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Biomedicines. 2024-2-21

[4]
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[5]
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[6]
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[7]
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[8]
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本文引用的文献

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