Yan Ju, Madina Mahesutihan, Deng Changjiang, Yuan Qianru, Cao Shixiong, Xie Xiang, Ma Yitong
The First Affiliated Hospital of Xinjiang Medical University, Ürümqi, China.
Department of Cardiology, The First Affiliated Hospital of Xinjiang Medical University, Ürümqi, China.
Front Cardiovasc Med. 2021 Oct 26;8:732193. doi: 10.3389/fcvm.2021.732193. eCollection 2021.
To summarize the clinical features, hematology and imaging features of Takotsubo syndrome. The hospitalization data of Takotsubo syndrome patients in the First Affiliated Hospital of Xinjiang Medical University from January 2015 to December 2020 were collected, and their clinical characteristics were summarized. Patient outcomes were clarified through follow-up visits, and relevant objective indicators were statistically analyzed before and after admission. The characteristics of TTS incidence in Chinese population were summarized by searching three (Wanfang, CNKI, China's VIP database) major databases in China (PRISMA). A total of 9 patients were enrolled, including 6 females (66.7%). The mean age of onset was 46.4 years old, the median time from onset to treatment was 1 day. The main symptom of 8 cases (88.9%) was chest pain, 1 case had a main symptom of syncope, and 7 cases (77.8%) had mood fluctuations or mental stimulation as the main symptom of the disease. Paired -tests were conducted on routine blood, biochemical, coagulation, myocardial markers, inflammatory indicators and objective indicators of ECG before and after admission. The study found that the counts of white blood cells and neutrophils were statistically significant ( < 0.05). Prolongation of the QT interval was observed in all 9 patients. After a mean follow-up of 24 ± 28 months, no adverse cardiovascular events or recurrence occurred. Takotsubo syndrome is a group of clinical syndromes with emotional or somatic stimulation and chest pain as the main symptoms, partly accompanied by an increase in white blood cells, neutrophilic granulocyte count, creatine kinase, and troponin and is characterized by a prolonged QT interval and no obvious coronary stenosis. The prognosis is generally good, with few serious complications.
总结应激性心肌病的临床特征、血液学及影像学特征。收集新疆医科大学第一附属医院2015年1月至2020年12月应激性心肌病患者的住院资料，总结其临床特点。通过随访明确患者预后，并对入院前后相关客观指标进行统计学分析。在中国三大数据库（万方、知网、维普数据库）检索（PRISMA），总结中国人群应激性心肌病的发病特点。共纳入9例患者，其中女性6例（66.7%）。平均发病年龄46.4岁，发病至治疗的中位时间为1天。8例（88.9%）主要症状为胸痛，1例主要症状为晕厥，7例（77.8%）以情绪波动或精神刺激为主要发病诱因。对入院前后血常规、生化、凝血、心肌标志物、炎症指标及心电图客观指标进行配对检验。研究发现白细胞及中性粒细胞计数差异有统计学意义（<0.05）。9例患者均出现QT间期延长。平均随访24±28个月后，未发生不良心血管事件或复发。应激性心肌病是以情绪或躯体刺激及胸痛为主要症状，部分伴有白细胞、中性粒细胞计数、肌酸激酶及肌钙蛋白升高，QT间期延长且无明显冠状动脉狭窄为特征的一组临床综合征。预后一般良好，严重并发症少见。
