Department of Molecular Physiology, Zoological Institute, Kiel University, Kiel, Germany.
Airway Research Center North (ARCN), German Center for Lung Research (DZL), Kiel, Germany.
Aging (Albany NY). 2021 Nov 12;13(21):24017-24036. doi: 10.18632/aging.203692.
Tumors of the intestinal tract are among the most common tumor diseases in humans, but, like many other tumor entities, show an unsatisfactory prognosis with a need for effective therapies. To test whether nutritional interventions and a combination with a targeted therapy can effectively cure these cancers, we used the fruit fly as a model. In this system, we induced tumors by EGFR overexpression in intestinal stem cells. Limiting the amount of protein in the diet restored life span to that of control animals. In combination with a specific EGFR inhibitor, all major tumor-associated phenotypes could be rescued. This form of treatment was also successful in a real treatment scenario, which means when they started after the full tumor phenotype was expressed. In conclusion, reduced protein administration can be a very promising form of adjuvant cancer therapy.
肠道肿瘤是人类最常见的肿瘤疾病之一，但与许多其他肿瘤实体一样，其预后不理想，需要有效的治疗方法。为了测试营养干预和与靶向治疗相结合是否能有效治愈这些癌症，我们使用果蝇作为模型。在这个系统中，我们通过在肠干细胞中过表达 EGFR 来诱导肿瘤。限制饮食中的蛋白质含量可以将寿命恢复到对照动物的水平。与特定的 EGFR 抑制剂联合使用，可以挽救所有主要的与肿瘤相关的表型。这种治疗方法在实际治疗场景中也取得了成功，这意味着当它们在完全表达肿瘤表型后开始使用。总之，减少蛋白质的摄入可能是一种非常有前途的辅助癌症治疗形式。
