细胞大小是衰老过程中干细胞潜能的一个决定因素。
Cell size is a determinant of stem cell potential during aging.
作者信息
Lengefeld Jette, Cheng Chia-Wei, Maretich Pema, Blair Marguerite, Hagen Hannah, McReynolds Melanie R, Sullivan Emily, Majors Kyra, Roberts Christina, Kang Joon Ho, Steiner Joachim D, Miettinen Teemu P, Manalis Scott R, Antebi Adam, Morrison Sean J, Lees Jacqueline A, Boyer Laurie A, Yilmaz Ömer H, Amon Angelika
机构信息
David H. Koch Institute for Integrative Cancer Research, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA, USA.
Institute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland.
出版信息
Sci Adv. 2021 Nov 12;7(46):eabk0271. doi: 10.1126/sciadv.abk0271.
Stem cells are remarkably small. Whether small size is important for stem cell function is unknown. We find that hematopoietic stem cells (HSCs) enlarge under conditions known to decrease stem cell function. This decreased fitness of large HSCs is due to reduced proliferation and was accompanied by altered metabolism. Preventing HSC enlargement or reducing large HSCs in size averts the loss of stem cell potential under conditions causing stem cell exhaustion. Last, we show that murine and human HSCs enlarge during aging. Preventing this age-dependent enlargement improves HSC function. We conclude that small cell size is important for stem cell function in vivo and propose that stem cell enlargement contributes to their functional decline during aging.
干细胞非常小。细胞体积小对干细胞功能是否重要尚不清楚。我们发现，造血干细胞（HSC）在已知会降低干细胞功能的条件下会增大。大型造血干细胞适应性的降低是由于增殖减少所致，并且伴随着代谢改变。在导致干细胞耗竭的条件下，防止造血干细胞增大或减小大型造血干细胞的大小可避免干细胞潜能的丧失。最后，我们表明，小鼠和人类造血干细胞在衰老过程中会增大。防止这种与年龄相关的增大可改善造血干细胞功能。我们得出结论，小细胞体积对体内干细胞功能很重要，并提出干细胞增大是其在衰老过程中功能衰退的原因。
Zotero 插件