大鼠肾脏中的Ia抗原，特别提及它们在肾小管上皮中的表达。
Ia antigens in rat kidney, with special reference to their expression in tubular epithelium.
作者信息
Mayrhofer G, Schon-Hegrad M A
出版信息
J Exp Med. 1983 Jun 1;157(6):2097-109. doi: 10.1084/jem.157.6.2097.
Abstract
The distribution of Ia antigens in rat kidneys has been investigated by an immunoperoxidase technique, using monoclonal antibodies directed at framework determinants on molecules equivalent to gene products of the I-A and I-E/C regions of the mouse major histocompatibility complex (MHC). Antigens mapping to both loci were detected in proximal convoluted tubule epithelium and on scattered dendritic cells in the interstitial connective tissues, glomeruli, and mucosa of the renal pelvis. All other structures were negative. Genetic studies indicate that the levels of expression of Ia molecules from both genetic loci are controlled by non-MHC genes in epithelium, but not on lymphocytes. The subcellular distribution of Ia molecules has been investigated in tubular epithelium and is discussed in relation to their possible functions in epithelia.
摘要
采用免疫过氧化物酶技术，使用针对与小鼠主要组织相容性复合体（MHC）I-A和I-E/C区域基因产物等效分子上构架决定簇的单克隆抗体，研究了大鼠肾脏中Ia抗原的分布。在近曲小管上皮以及肾间质结缔组织、肾小球和肾盂黏膜中的散在树突状细胞上，检测到了定位在这两个位点的抗原。所有其他结构均为阴性。遗传学研究表明，上皮细胞中来自这两个基因位点的Ia分子表达水平受非MHC基因控制，但淋巴细胞不受其控制。已对肾小管上皮细胞中Ia分子的亚细胞分布进行了研究，并就其在上皮细胞中的可能功能进行了讨论。
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