Poignet Barthelemy, Bonnin Philippe, Gaudric Julien, Chehaibou Ismael, Vautier Mathieu, Tadayoni Ramin, Gaudric Alain, Paques Michel, Bodaghi Bahram, Saadoun David, Bonnin Sophie
Ophthalmology Department, Hopital Pitié Salpêtrière, Sorbonne University, 75013 Paris, France.
Clinical Physiology and Fonctionnal Explorations, Hôpital Lariboisière, University of Paris, 75010 Paris, France.
J Clin Med. 2021 Oct 24;10(21):4916. doi: 10.3390/jcm10214916.
(1) Background: Takayasu arteritis (TA) is a chronic inflammatory large-vessel vasculitis. Ultra-wide-field imaging allows describing the retinal lesions in these patients and correlating them with vascular supra-aortic stenosis. (2) Methods: In total, 54 eyes of 27 patients diagnosed with TA were included, and a complete ophthalmological examination was performed, including UWF color fundus photography (UWF-CFP), fluorescein angiography (UWF-FA), and computed tomography angiography measuring supra-aortic stenosis. Eleven patients underwent Doppler ultrasound imaging assessing the blood flow velocity (BFV) in the central retinal artery (CRA). (3) Results: Microaneurysms were detected in 18.5% of eyes on fundus examination, in 24.4% of eyes on UWF-CFP, and in 94.4% of eyes on UWF-FA. The number of microaneurysms significantly correlated with the presence of an ipsilateral supra-aortic stenosis ( = 0.026), the presence of hypertension ( = 0.0011), and the duration of the disease ( = 0.007). The number of microaneurysms per eye negatively correlated with the BFV in the CRA (r = -0.61; = 0.003). (4) Conclusions: UWF-FA improved the assessment of TA-associated retinal findings. The significant correlation between the number of microaneurysms and the BFV in the CRA gives new insight to our understanding of Takayasu retinopathy. The total number of microaneurysms could be used as an interesting prognostic factor for TA.
(1) 背景：大动脉炎（TA）是一种慢性炎症性大血管血管炎。超广角成像能够描述这些患者的视网膜病变，并将其与主动脉弓上狭窄相关联。(2) 方法：共纳入27例诊断为TA的患者的54只眼，进行了全面的眼科检查，包括超广角彩色眼底照相（UWF-CFP）、荧光素血管造影（UWF-FA）以及测量主动脉弓上狭窄的计算机断层血管造影。11例患者接受了多普勒超声成像，评估视网膜中央动脉（CRA）的血流速度（BFV）。(3) 结果：眼底检查中18.5%的眼检测到微动脉瘤，UWF-CFP检查中24.4%的眼检测到微动脉瘤，UWF-FA检查中94.4%的眼检测到微动脉瘤。微动脉瘤的数量与同侧主动脉弓上狭窄的存在（P = 0.026）、高血压的存在（P = 0.0011）以及疾病持续时间（P = 0.007）显著相关。每只眼的微动脉瘤数量与CRA中的BFV呈负相关（r = --0.61；P = 0.003）。(4) 结论：UWF-FA改善了对TA相关视网膜表现的评估。微动脉瘤数量与CRA中BFV之间的显著相关性为我们理解大动脉炎视网膜病变提供了新的见解。微动脉瘤的总数可作为TA一个有趣的预后因素。
