LAQV-REQUIMTE, Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, Rua do Campo Alegre 687, P-4169-007 Porto, Portugal.
Ciências Químicas e das Biomoléculas, CISA, Escola Superior de Saúde, Politécnico do Porto, R. Dr. António Bernardino de Almeida 400, P-4200-072 Porto, Portugal.
Int J Mol Sci. 2021 Nov 5;22(21):11991. doi: 10.3390/ijms222111991.
Topical and transdermal delivery systems are of undeniable significance and ubiquity in healthcare, to facilitate the delivery of active pharmaceutical ingredients, respectively, onto or across the skin to enter systemic circulation. From ancient ointments and potions to modern micro/nanotechnological devices, a variety of approaches has been explored over the ages to improve the skin permeation of diverse medicines and cosmetics. Amongst the latest investigational dermal permeation enhancers, ionic liquids have been gaining momentum, and recent years have been prolific in this regard. As such, this review offers an outline of current methods for enhancing percutaneous permeation, highlighting selected reports where ionic liquid-based approaches have been investigated for this purpose. Future perspectives on use of ionic liquids for topical delivery of bioactive peptides are also presented.
透皮和局部给药系统在医疗保健中具有不可否认的重要性和普遍性，分别将活性药物成分递送至或穿过皮肤进入体循环。从古至今，人们一直在探索各种方法，从古代的软膏和药水到现代的微/纳米技术设备，以改善各种药物和化妆品的皮肤渗透。在最新的研究性皮肤渗透增强剂中，离子液体越来越受到关注，近年来在这方面取得了丰硕的成果。因此，本文概述了目前增强经皮渗透的方法，重点介绍了一些研究离子液体在这方面应用的报告。本文还对离子液体在生物活性肽局部给药中的应用前景进行了展望。
