Moilanen E, Seppälä E, Nissilä M, Vapaatalo H
Prostaglandins Leukot Med. 1987 Jul;28(2):141-52. doi: 10.1016/0262-1746(87)90159-4.
The effect of D-penicillamine (DPA) on immunoreactive prostanoid concentrations was studied in a primary culture of adherent synovial cells from patients suffering from rheumatoid arthritis (RA). DPA in clinically achievable concentrations increased the levels of prostaglandin E2 (PGE2) and thromboxane B2 (TXB2) and reduced those of 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha) synthetized from endogenous substrate. The capacity for PGE2 and 6-keto-PGF1 alpha production in the presence of exogenous arachidonic acid was decreased by DPA. These effects may be connected with the antirheumatic and immunosuppressive action of DPA.
在类风湿性关节炎（RA）患者的贴壁滑膜细胞原代培养物中研究了D-青霉胺（DPA）对免疫反应性前列腺素浓度的影响。临床可达到浓度的DPA可提高前列腺素E2（PGE2）和血栓素B2（TXB2）的水平，并降低由内源性底物合成的6-酮-前列腺素F1α（6-酮-PGF1α）的水平。DPA可降低在外源性花生四烯酸存在下PGE2和6-酮-PGF1α的产生能力。这些作用可能与DPA的抗风湿和免疫抑制作用有关。
