Sautour Marc, Mitaine-Offer Anne-Claire, Miyamoto Tomofumi, Dongmo Alain, Lacaille-Dubois Marie-Aleth
Laboratoire de Pharmacognosie, Unité UMIB, EA 3660, Faculté de Pharmacie, Université de Bourgogne, 7 Boulevard Jeanne d'Arc, BP 87900, 21079 Dijon Cedex, France.
Chem Pharm Bull (Tokyo). 2004 Nov;52(11):1353-5. doi: 10.1248/cpb.52.1353.
The new 26-O-beta-D-glucopyranosyl-3beta,26-dihydroxy-20,22-seco-25(R)-furost-5-en-20,22-dione-3-O-alpha-L-rhamnopyranosyl-(1-->4)-alpha-L-rhamnopyranosyl-(1-->4)-[alpha-L-rhamnopyranosyl-(1-->2)]-beta-D-glucopyranoside (1), along with the known methyl protodioscin (2), asperoside (3) and prosapogenin A of dioscin (4) were isolated from the rhizomes of Dioscorea cayenensis LAM.-HOLL (Dioscoreaceae). Their structures were established mainly on the basis of 600 MHz 2D-NMR spectral data. 4 exhibited antifungal activity against the human pathogenic yeasts Candida albicans, C. glabrata and C. tropicalis (MICs of 20.8, 6.25, 25 microg/ml, respectively), whereas saponins 1-3 were inactive.
从薯蓣科植物卡宴薯蓣（Dioscorea cayenensis LAM.-HOLL）的根茎中分离得到了新的26 - O - β - D - 吡喃葡萄糖基 - 3β,26 - 二羟基 - 20,22 - 断 - 25(R) - 呋甾 - 5 - 烯 - 20,22 - 二酮 - 3 - O - α - L - 鼠李吡喃糖基 - (1→4) - α - L - 鼠李吡喃糖基 - (1→4) - [α - L - 鼠李吡喃糖基 - (1→2)] - β - D - 吡喃葡萄糖苷（1），以及已知的甲基原薯蓣皂苷（2）、阿魏糖苷（3）和薯蓣皂苷元A（4）。它们的结构主要基于600 MHz的二维核磁共振光谱数据确定。化合物4对人类致病酵母白色念珠菌、光滑念珠菌和热带念珠菌表现出抗真菌活性（最小抑菌浓度分别为20.8、6.25、25 μg/ml），而皂苷1 - 3没有活性。
