Rosenquist Aske Hess, Høyer Birgit Bjerre, Julvez Jordi, Sunyer Jordi, Pedersen Henning Sloth, Lenters Virissa, Jönsson Bo A G, Bonde Jens Peter, Toft Gunnar
Department of Clinical Epidemiology, Aarhus University Hospital , Aarhus, Denmark.
Department of Occupational and Environmental Medicine, Copenhagen University Hospital , Copenhagen, Denmark.
Environ Health Perspect. 2017 Oct 3;125(10):107002. doi: 10.1289/EHP553.
Studies have reported some evidence of adverse effects of organochlorine exposures on child development, but the results have been inconsistent, and few studies have evaluated associations with child behavior.
We investigated the association between prenatal and early-life exposures to 2,2',4,4',5,5'-hexachlorobiphenyl (PCB-153) and 1,1-dichloro-2,2-bis(-chlorophenyl)-ethylene ('-DDE) and behaviors in children between 5 and 9 y of age.
In the Biopersistent organochlorines in diet and human fertility: Epidemiologic studies of time to pregnancy and semen quality in Inuit and European populations (INUENDO) cohort, consisting of mother-child pairs from Greenland and Ukraine (=1,018), maternal serum PCB-153 and '-DDE concentrations were measured during pregnancy, and cumulative postnatal exposures during the first 12 months after delivery were estimated using a pharmacokinetic model. Parents completed the Strengths and Difficulties Questionnaire (SDQ), and children's behaviors were dichotomized as abnormal (high) versus normal/borderline for five SDQ subscales and the total difficulties score.
The total difficulties score, an overall measure of abnormal behavior, was not clearly associated with pre- or postnatal exposures to PCB-153 or to '-DDE. However, pooled adjusted odds ratios (ORs) for high conduct problem scores with a doubling of exposure were 1.19 (95% CI: 0.99, 1.42) and 1.16 (95% CI: 0.96, 1.41) for pre- and postnatal PCB-153, respectively, and 1.25 (95% CI: 1.04, 1.51) and 1.24 (95% CI: 1.01, 1.51) for pre- and postnatal '-DDE, respectively. Corresponding ORs for high hyperactivity scores were 1.24 (95% CI: 0.94, 1.62) and 1.08 (95% CI: 0.81, 1.45) for pre- and postnatal PCB-153, respectively, and 1.43 (95% CI: 1.06, 1.92) and 1.27 (95% CI: 0.93, 1.73) for pre- and postnatal '-DDE, respectively.
Prenatal and early postnatal exposures to '-DDE and PCB-153 were associated with a higher prevalence of abnormal scores for conduct and hyperactivity at 5–9 y of age in our study population. These findings provide further support for the importance of minimizing organochlorine exposures to young children and to women of childbearing age. https://doi.org/10.1289/EHP553.
研究报告了一些有机氯暴露对儿童发育产生不良影响的证据，但结果并不一致，且很少有研究评估其与儿童行为的关联。
我们调查了产前和生命早期暴露于2,2',4,4',5,5'-六氯联苯（PCB-153）和1,1-二氯-2,2-双（-氯苯基）乙烯（'-DDE）与5至9岁儿童行为之间的关联。
在饮食和人类生育中的生物持久性有机氯：因纽特人和欧洲人群怀孕时间和精液质量的流行病学研究（INUENDO）队列中，该队列由来自格陵兰和乌克兰的母婴对（=1018）组成，在孕期测量了母亲血清中PCB-153和'-DDE的浓度，并使用药代动力学模型估算了分娩后前12个月的累积产后暴露量。父母完成了优势与困难问卷（SDQ），并将儿童行为在五个SDQ子量表和总困难得分方面分为异常（高）与正常/临界。
总困难得分是异常行为的总体衡量指标，与产前或产后暴露于PCB-153或'-DDE并无明显关联。然而，产前和产后PCB-153暴露量翻倍时，高品行问题得分的合并调整优势比（OR）分别为1.19（95%CI：0.99，1.42）和1.16（95%CI：0.96，1.41），产前和产后'-DDE的相应OR分别为1.25（95%CI：1.04，1.51）和1.24（95%CI：1.01，1.51）。产前和产后PCB-153高多动得分的相应OR分别为1.24（95%CI：0.94，1.62）和1.08（95%CI：_0.81，1.45），产前和产后'-DDE的相应OR分别为1.43（95%CI：1.06，1.92）和1.27（95%CI：0.93，1.73）。
在我们的研究人群中，产前和产后早期暴露于'-DDE和PCB-153与5至9岁儿童品行和多动异常得分的较高患病率相关。这些发现进一步支持了尽量减少幼儿和育龄妇女有机氯暴露的重要性。https://doi.org/10.1289/EHP553
