Department of Pediatrics, Pediatric Infectious Disease Unit, İstanbul University Faculty of Medicine, İstanbul, Turkey
Turk J Med Sci. 2021 Dec 17;51(SI-1):3273-3283. doi: 10.3906/sag-2105-342.
As the COVID-19 pandemic continues, children can be infected with the virus that causes COVID-19. Clinical symptoms of children with COVID from China, where the disease was first reported, generally were less severe than adults. However, at the end of April 2020 in Europe, it was observed that some children with SARS-CoV-2 infection developed fever, abdominal pain, shock, myocardial insufficiency and they needed to be taken care of in intensive care unit. This new disease has been called multisystem inflammatory syndrome in children (MIS-C). Although the pathogenesis of MIS-C is unclear, it progresses with signs of multiorgan involvement as a result of uncontrolled inflammation of the immune system and even causes death. Therefore, the diagnosis and treatment of patients with MIS-C should be managed quickly. In this review, the pathophysiology, clinical and laboratory findings, diagnostic methods, and treatment regimens of MIS-C were discussed.
随着 COVID-19 大流行的持续，儿童也可能感染导致 COVID-19 的病毒。中国是首次报告该疾病的国家，其儿童 COVID 的临床症状通常比成年人轻。然而，在 2020 年 4 月底的欧洲，观察到一些 SARS-CoV-2 感染的儿童出现发热、腹痛、休克、心肌功能不全，他们需要在重症监护病房接受治疗。这种新疾病被称为儿童多系统炎症综合征（MIS-C）。尽管 MIS-C 的发病机制尚不清楚，但它会随着免疫系统失控性炎症导致多器官受累的迹象进展，甚至导致死亡。因此，应迅速对 MIS-C 患者进行诊断和治疗。在这篇综述中，讨论了 MIS-C 的病理生理学、临床和实验室发现、诊断方法和治疗方案。
