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COVID-19-associated multisystem inflammatory syndrome in children (MIS-C): A novel disease that mimics toxic shock syndrome-the superantigen hypothesis.

作者信息

Noval Rivas Magali, Porritt Rebecca A, Cheng Mary Hongying, Bahar Ivet, Arditi Moshe

机构信息

Division of Pediatric Infectious Diseases and Immunology, Department of Biomedical Sciences, Infectious and Immunologic Diseases Research Center, Cedars-Sinai Medical Center, Los Angeles, Calif; Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, Calif.

Division of Pediatric Infectious Diseases and Immunology, Department of Biomedical Sciences, Infectious and Immunologic Diseases Research Center, Cedars-Sinai Medical Center, Los Angeles, Calif.

出版信息

J Allergy Clin Immunol. 2021 Jan;147(1):57-59. doi: 10.1016/j.jaci.2020.10.008. Epub 2020 Oct 16.

DOI:10.1016/j.jaci.2020.10.008
PMID:33075409
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7564502/
Abstract
摘要

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本文引用的文献

1
Superantigenic character of an insert unique to SARS-CoV-2 spike supported by skewed TCR repertoire in patients with hyperinflammation.一种独特插入序列赋予 SARS-CoV-2 刺突蛋白超级抗原特性，导致炎症反应患者 TCR 谱发生偏倚。
Proc Natl Acad Sci U S A. 2020 Oct 13;117(41):25254-25262. doi: 10.1073/pnas.2010722117. Epub 2020 Sep 28.
2
The Immunology of Multisystem Inflammatory Syndrome in Children with COVID-19.儿童 COVID-19 相关多系统炎症综合征的免疫学。
Cell. 2020 Nov 12;183(4):968-981.e7. doi: 10.1016/j.cell.2020.09.016. Epub 2020 Sep 6.
3
Neurological associations of COVID-19.
儿童多系统炎症综合征（MIS-C）的临床表现、诊断和治疗：系统评价。
BMJ Paediatr Open. 2024 Jun 6;8(1):e002344. doi: 10.1136/bmjpo-2023-002344.
4
Proteomic profiling reveals diagnostic signatures and pathogenic insights in multisystem inflammatory syndrome in children.蛋白质组学分析揭示了儿童多系统炎症综合征的诊断特征和发病机制见解。
Commun Biol. 2024 Jun 5;7(1):688. doi: 10.1038/s42003-024-06370-8.
5
COVID-19 and cardiac complications: Myocarditis and multisystem inflammatory syndrome in children.2019冠状病毒病与心脏并发症：儿童心肌炎和多系统炎症综合征
World J Cardiol. 2024 May 26;16(5):260-268. doi: 10.4330/wjc.v16.i5.260.
6
Novel insights into the immune response to bacterial T cell superantigens.对细菌 T 细胞超抗原免疫反应的新认识。
Nat Rev Immunol. 2024 Jun;24(6):417-434. doi: 10.1038/s41577-023-00979-2. Epub 2024 Jan 15.
7
The spike-specific TCRβ repertoire shows distinct features in unvaccinated or vaccinated patients with SARS-CoV-2 infection.在未接种疫苗或接种过 SARS-CoV-2 疫苗的患者中，刺突特异性 TCRβ 库具有明显特征。
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Clinical Characteristics of 58 Children With a Pediatric Inflammatory Multisystem Syndrome Temporally Associated With SARS-CoV-2.58 例与 SARS-CoV-2 相关的儿童炎症性多系统综合征的临床特征。
JAMA. 2020 Jul 21;324(3):259-269. doi: 10.1001/jama.2020.10369.
5
Multisystem Inflammatory Syndrome Related to COVID-19 in Previously Healthy Children and Adolescents in New York City.纽约市先前健康的儿童和青少年与 COVID-19 相关的多系统炎症综合征。
JAMA. 2020 Jul 21;324(3):294-296. doi: 10.1001/jama.2020.10374.
6
Novel paediatric presentation of COVID-19 with ARDS and cytokine storm syndrome without respiratory symptoms.新型冠状病毒肺炎（COVID-19）在儿童中的新表现：伴有急性呼吸窘迫综合征（ARDS）和细胞因子风暴综合征，且无呼吸道症状
Lancet Rheumatol. 2020 Jul;2(7):e376-e379. doi: 10.1016/S2665-9913(20)30137-5. Epub 2020 May 15.
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8
Binding of superantigen toxins into the CD28 homodimer interface is essential for induction of cytokine genes that mediate lethal shock.超抗原毒素与 CD28 同源二聚体界面的结合对于诱导介导致死性休克的细胞因子基因是必需的。
PLoS Biol. 2011 Sep;9(9):e1001149. doi: 10.1371/journal.pbio.1001149. Epub 2011 Sep 13.
9
Engagement of MHC class II molecules by staphylococcal superantigens activates src-type protein tyrosine kinases.葡萄球菌超抗原与II类主要组织相容性复合体分子的结合激活src型蛋白酪氨酸激酶。
Eur J Immunol. 1994 Mar;24(3):651-8. doi: 10.1002/eji.1830240325.
10
Persistent neuropsychological sequelae of toxic shock syndrome.
Ann Intern Med. 1982 Jun;96(6 Pt 2):865-70. doi: 10.7326/0003-4819-96-6-865.