Department of Clinical Laboratory, Third Affiliated Hospital of Guangzhou Medical University, No. 63 Duobao Road, Liwan District, Guangzhou, Guangdong, 510150, PR China; Department of Biomedical Engineering, Southern University of Science and Technology, No 1088, Xueyuan Rd., Xili, Nanshan District, Shenzhen, Guangdong, 518055, PR China.
Department of Clinical Laboratory, Third Affiliated Hospital of Guangzhou Medical University, No. 63 Duobao Road, Liwan District, Guangzhou, Guangdong, 510150, PR China.
Biosens Bioelectron. 2022 Feb 1;197:113765. doi: 10.1016/j.bios.2021.113765. Epub 2021 Nov 9.
Wearable epidermal patch can seamlessly monitor biological signals in real-time. Here, we report a liquid metal-polymer conductor-based wireless epidermal patch. The epidermal patch is made of a new conductive material called liquid metal-polymer conductors (LMPC). LMPC is made by casting and peeling off polymers from patterned liquid metal particles. Our printable conductors present good stretchability, repeatability, and biocompatibility. We fabricate LMPC-based antenna and wire, which achieves wireless signal communication and power supply. To demonstrate the capability of our LMPC-based antenna and wire, we fabricate an epidermal patch to analyze metabolites, electrolytes, and urea in sweat. When a portable device is close to the epidermal sensor, the device can power and read the sensor through LMPC-based antenna. The epidermal patch exhibited good analytical performance for sweat analysis with a low limit of detection, fast response time, and multiplex detection capabilities. This epidermal patch opens the possibility for a broad range of non-invasive diagnostic tools that can be used for health monitoring in the general population.
可穿戴表皮贴片可实时无缝监测生物信号。在这里，我们报告了一种基于液态金属-聚合物导体的无线表皮贴片。该表皮贴片由一种称为液态金属-聚合物导体 (LMPC) 的新型导电材料制成。LMPC 通过从图案化的液态金属颗粒上浇铸和剥离聚合物来制造。我们的可印刷导体具有良好的拉伸性、可重复性和生物相容性。我们制造了基于 LMPC 的天线和电线，实现了无线信号通信和供电。为了展示我们基于 LMPC 的天线和电线的功能，我们制造了一种表皮贴片来分析汗液中的代谢物、电解质和尿素。当便携式设备靠近表皮传感器时，设备可以通过基于 LMPC 的天线为传感器供电并读取传感器。表皮贴片在汗液分析方面表现出良好的分析性能，具有低检测限、快速响应时间和多路检测能力。这种表皮贴片为广泛的非侵入性诊断工具开辟了可能性，可用于普通人群的健康监测。
