Research & Development Institute, House Wellness Foods Corp., 3-20 Imoji, Itami, Hyogo, 664-0011, Japan.
Nutr J. 2021 Nov 13;20(1):91. doi: 10.1186/s12937-021-00748-8.
The dietary spice Curcuma longa, also known as turmeric, has various biological effects. Both a water extract and a supercritical carbon dioxide extract of C. longa showed anti-inflammatory activities in animal studies. However, the anti-inflammatory effect in humans of a mixture of these two C. longa extracts (CLE) is poorly understood. Therefore, we investigated the effect of CLE containing anti-inflammatory turmeronols on chronic inflammation and general health.
We performed a randomized, double-blind, placebo-controlled study in healthy subjects aged 50 to 69 years with overweight. Participants took two capsules containing CLE (CLE group, n = 45) or two placebo capsules (placebo group, n = 45) daily for 12 weeks, and serum inflammatory markers were measured. Participants also completed two questionnaires: the Medical Outcomes Study (MOS) 36-Item Short-Form Health Survey (SF-36) and the Profile of Mood States (POMS) scale. Treatment effects were analyzed by two way analysis of variance followed by a t test (significance level, p < 0.05).
After the intervention, the CLE group had a significantly lower body weight (p < 0.05) and body mass index (p < 0.05) than the placebo group and significantly lower serum levels of C-reactive protein (p < 0.05) and complement component 3 (p < 0.05). In addition, the CLE group showed significant improvement of the MOS SF-36 mental health score (p < 0.05) and POMS anger-hostility score (p < 0.05).
CLE may ameliorate chronic low-grade inflammation and thus help to improve mental health and mood disturbance.
UMIN-CTR, UMIN000037370. Registered 14 July 2019, https://upload.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000042607.
食用香料姜黄，又称 turmeric，具有多种生物学效应。姜黄的水提取物和超临界二氧化碳提取物在动物研究中均表现出抗炎活性。然而，混合这两种姜黄提取物（CLE）对人类的抗炎作用知之甚少。因此，我们研究了含有抗炎 turmeronols 的 CLE 对慢性炎症和整体健康的影响。
我们在 50 至 69 岁超重的健康受试者中进行了一项随机、双盲、安慰剂对照研究。参与者每天服用两粒含有 CLE（CLE 组，n=45）或两粒安慰剂胶囊（安慰剂组，n=45），持续 12 周，并测量血清炎症标志物。参与者还完成了两份问卷：医疗结果研究（MOS）36 项简短健康调查（SF-36）和心境状态问卷（POMS）量表。采用双因素方差分析和 t 检验分析治疗效果（显著性水平，p<0.05）。
干预后，CLE 组的体重（p<0.05）和体重指数（p<0.05）明显低于安慰剂组，血清 C 反应蛋白（p<0.05）和补体成分 3（p<0.05）水平明显降低。此外，CLE 组的 MOS SF-36 心理健康评分（p<0.05）和 POMS 愤怒-敌意评分（p<0.05）显著改善。
CLE 可能改善慢性低度炎症，从而有助于改善心理健康和情绪障碍。
UMIN-CTR，UMIN000037370。注册于 2019 年 7 月 14 日，https://upload.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi？recptno=R000042607。
