谷氨酸：主要神经递质及其在慢性应激和情绪障碍中的意义
Glutamate: The Master Neurotransmitter and Its Implications in Chronic Stress and Mood Disorders.
作者信息
Pal Mia Michaela
机构信息
In Cognition UK, Church Lawton, United Kingdom.
出版信息
Front Hum Neurosci. 2021 Oct 29;15:722323. doi: 10.3389/fnhum.2021.722323. eCollection 2021.
Abstract
This brief review article makes the argument that glutamate is deserving of its newfound attention within the neuroscience literature and that many directions of important research have yet to be explored. Glutamate is an excitatory neurotransmitter with several types of receptors found throughout the central nervous system, and its metabolism is important to maintaining optimal levels within the extracellular space. As such, it is important to memory, cognition, and mood regulation. The mechanisms by which chronic stress affect the glutamatergic system and neuroplasticity are outlined. Several implications for potential pharmacologic and non-pharmacologic interventions are discussed.
摘要
这篇简短的综述文章认为，谷氨酸在神经科学文献中值得受到新的关注，并且许多重要的研究方向尚未得到探索。谷氨酸是一种兴奋性神经递质，在整个中枢神经系统中发现有几种类型的受体，其代谢对于维持细胞外空间内的最佳水平很重要。因此，它对记忆、认知和情绪调节很重要。文中概述了慢性应激影响谷氨酸能系统和神经可塑性的机制。还讨论了潜在的药物和非药物干预措施的若干影响。
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