Institute of Microelectronics of Chinese Academy of Sciences, Beijing, China; University of Chinese Academy of Sciences, Beijing, China.
Department of Pulmonary and Critical Care Medicine, Peking University Third Hospital, Beijing, China.
Comput Biol Med. 2022 Feb;141:105003. doi: 10.1016/j.compbiomed.2021.105003. Epub 2021 Nov 3.
The coronavirus disease (COVID-19) effected a global health crisis in 2019, 2020, and beyond. Currently, methods such as temperature detection, clinical manifestations, and nucleic acid testing are used to comprehensively determine whether patients are infected with the severe acute respiratory syndrome coronavirus 2. However, during the peak period of COVID-19 outbreaks and in underdeveloped regions, medical staff and high-tech detection equipment were limited, resulting in the continued spread of the disease. Thus, a more portable, cost-effective, and automated auxiliary screening method is necessary.
We aim to apply a machine learning algorithm and non-contact monitoring system to automatically screen potential COVID-19 patients.
We used impulse-radio ultra-wideband radar to detect respiration, heart rate, body movement, sleep quality, and various other physiological indicators. We collected 140 radar monitoring data from 23 COVID-19 patients in Wuhan Tongji Hospital and compared them with 144 radar monitoring data from healthy controls. Then, the XGBoost and logistic regression (XGBoost + LR) algorithms were used to classify the data according to patients and healthy subjects.
The XGBoost + LR algorithm demonstrated excellent discrimination (precision = 92.5%, recall rate = 96.8%, AUC = 98.0%), outperforming other single machine learning algorithms. Furthermore, the SHAP value indicates that the number of apneas during REM, mean heart rate, and some sleep parameters are important features for classification.
The XGBoost + LR-based screening system can accurately predict COVID-19 patients and can be applied in hotels, nursing homes, wards, and other crowded locations to effectively help medical staff.
2019 年至 2020 年及以后,冠状病毒病(COVID-19)引发了全球卫生危机。目前,综合判断患者是否感染严重急性呼吸综合征冠状病毒 2 的方法有体温检测、临床表现和核酸检测等。然而,在 COVID-19 疫情高峰期和欠发达地区,医护人员和高科技检测设备有限,导致疾病继续传播。因此,需要一种更便携、更具成本效益且自动化的辅助筛选方法。
我们旨在应用机器学习算法和非接触式监测系统来自动筛选潜在的 COVID-19 患者。
我们使用冲激无线电超宽带雷达来检测呼吸、心率、身体运动、睡眠质量和其他各种生理指标。我们从武汉同济医院的 23 名 COVID-19 患者中收集了 140 个雷达监测数据,并将其与 144 个健康对照者的雷达监测数据进行了比较。然后,我们使用 XGBoost 和逻辑回归(XGBoost+LR)算法根据患者和健康受试者对数据进行分类。
XGBoost+LR 算法表现出出色的判别能力(精度=92.5%,召回率=96.8%,AUC=98.0%),优于其他单一的机器学习算法。此外,SHAP 值表明 REM 期间的呼吸暂停次数、平均心率和一些睡眠参数是分类的重要特征。
基于 XGBoost+LR 的筛选系统可以准确预测 COVID-19 患者,并可应用于酒店、养老院、病房等拥挤场所,有效帮助医务人员。