Potts A J, Hamburger J, Scully C
Birmingham Dental School.
Oral Surg Oral Med Oral Pathol. 1987 Nov;64(5):541-3. doi: 10.1016/0030-4220(87)90029-6.
While the cause of lichen planus remains unclear, a number of drugs are known to produce oral and cutaneous lesions that clinically and histologically resemble lichen planus. In this study, the medication taken by 225 consecutive patients with oral lichen planus was compared with the drug histories of 202 age- and gender-matched control patients who were treated at the same clinics. Fifty-three percent of the patients with lichen planus and 44% of the control patients were taking one or more drugs (p greater than 0.05). However, 17% of the patients with lichen planus were taking nonsteroidal anti-inflammatory drugs (NSAID) compared with 9% of the control patients (p less than 0.05). There were no significant differences in the use of antihypertensive, oral hypoglycemic, or psychotropic drugs between the two groups. Almost 30% of the patients with the more severe erosive form of lichen planus were taking NSAID while fewer than 9% of the patients without erosions were taking this type of medication indicating a relationship between NSAID and the more severe form of lichen planus (p less than 0.01). Withdrawal from NSAID resulted in resolution or marked clinical improvement in the 12 patients tested. These results indicate that oral lichen planus may be aggravated or precipitated by NSAID and that withdrawal from the drug may benefit some patients.
虽然扁平苔藓的病因尚不清楚，但已知一些药物会产生口腔和皮肤病变，这些病变在临床和组织学上与扁平苔藓相似。在本研究中，将225例连续性口腔扁平苔藓患者服用的药物与在同一诊所接受治疗的202例年龄和性别匹配的对照患者的用药史进行了比较。53%的扁平苔藓患者和44%的对照患者正在服用一种或多种药物（p>0.05）。然而，17%的扁平苔藓患者正在服用非甾体抗炎药（NSAID），而对照患者中这一比例为9%（p<0.05）。两组在使用抗高血压药、口服降糖药或精神药物方面没有显著差异。几乎30%的患有较严重糜烂型扁平苔藓的患者正在服用NSAID，而没有糜烂的患者中服用这类药物的不到9%，这表明NSAID与较严重的扁平苔藓形式之间存在关联（p<0.01）。对12例受试患者停用NSAID后，病情得到缓解或显著改善。这些结果表明，NSAID可能会加重或诱发口腔扁平苔藓，停用该药物可能会使一些患者受益。
