Van Dis M L, Parks E T
Department of Stomatology, Indiana University School of Dentistry, Indianapolis, USA.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1995 Jun;79(6):696-700. doi: 10.1016/s1079-2104(05)80302-6.
The purpose of this study was to determine the prevalence of oral lichen planus in a population of patients with diabetes mellitus compared with a control population and to determine if patient medications had any influence on the presence of such lesions. Two hundred seventy-three patients with diabetes and an identical number of age-, gender- and race-matched controls were examined for clinical evidence of oral lichen planus. Patient medication histories were also obtained from each group. Eleven diabetic patients (4%) and eight control patients (3%) had clinical evidence of oral lichen planus. Ingestion of nonsteroidal anti-inflammatory drugs or angiotensin-converting enzyme inhibitors was associated with the presence of oral lichen planus lesions in six patients. There was no apparent association of diabetes and oral lichen planus in this population, and the ingestion of medications known to cause lichenoid mucosal reactions had no influence per se on the presence of oral lichen planus lesions (p > 0.05). However, the type of medication ingested by those patients who had oral lichen planus lesions was either nonsteroidal anti-inflammatory drug or angiotensin-converting enzyme inhibitor, which was a significant association (p < 0.00).
本研究的目的是确定糖尿病患者群体中口腔扁平苔藓的患病率，并与对照组人群进行比较，同时确定患者所服用的药物是否对这类病损的存在有任何影响。对273例糖尿病患者以及数量相同、年龄、性别和种族匹配的对照组进行检查，以寻找口腔扁平苔藓的临床证据。还收集了每组患者的用药史。11例糖尿病患者（4%）和8例对照患者（3%）有口腔扁平苔藓的临床证据。6例患者口服非甾体抗炎药或血管紧张素转换酶抑制剂与口腔扁平苔藓病损的存在有关。在该人群中，糖尿病与口腔扁平苔藓之间无明显关联，已知可引起苔藓样黏膜反应的药物摄入本身对口腔扁平苔藓病损的存在无影响（p>0.05）。然而，患有口腔扁平苔藓病损的患者所服用的药物类型为非甾体抗炎药或血管紧张素转换酶抑制剂，这是一种显著的关联（p<0.00）。
