Cook Nathan E, Iverson Grant L
Department of Physical Medicine and Rehabilitation, Harvard Medical School, Boston, MA, United States.
MassGeneral Hospital for Children Sports Concussion Program, Boston, MA, United States.
Front Neurol. 2021 Nov 1;12:773927. doi: 10.3389/fneur.2021.773927. eCollection 2021.
The objective of this study was to examine the incidence of concussion and risk factors for sustaining concussion among children from the United States general population. This prospective cohort study used data from the Adolescent Brain Cognitive Development (ABCD) Study. Children were recruited from schools across the US, sampled to reflect the sociodemographic variation of the US population. The current sample includes 11,013 children aged 9 to 10 years old (47.6% girls; 65.5% White) who were prospectively followed for an average of 1 year (mean = 367.9 days, SD = 40.8, range 249-601). The primary outcome was caregiver-reported concussion during a 1 year follow-up period. Logistic regression was used to determine which potential clinical, health history, and behavioral characteristics (assessed at baseline) were prospectively associated with concussion. In the 1 year follow-up period between ages 10 and 11, 1 in 100 children ( = 123, 1.1%) sustained a concussion. In univariate models, three baseline predictors (ADHD, prior concussion, and accident proneness) were significantly associated with sustaining a concussion. In a multivariate model, controlling for all other predictors, only prior concussion remained significantly associated with the occurrence of a concussion during the observation period (Odds Ratio = 5.49, 95% CI: 3.40-8.87). The most robust and only independent prospective predictor of sustaining a concussion was history of a prior concussion. History of concussion is associated with 5.5 times greater odds of sustaining concussion between ages 10 and 11 among children from the general US population.
本研究的目的是调查美国普通人群中儿童脑震荡的发生率以及发生脑震荡的风险因素。这项前瞻性队列研究使用了青少年大脑认知发展(ABCD)研究的数据。研究从美国各地的学校招募儿童,抽样以反映美国人口的社会人口统计学差异。当前样本包括11013名9至10岁的儿童(47.6%为女孩;65.5%为白人),对其进行了平均1年的前瞻性随访(平均 = 367.9天,标准差 = 40.8,范围249 - 601天)。主要结局是在1年随访期内由照料者报告的脑震荡情况。使用逻辑回归来确定哪些潜在的临床、健康史和行为特征(在基线时评估)与脑震荡存在前瞻性关联。在10至11岁的1年随访期内,每100名儿童中有1名(n = 123,1.1%)发生了脑震荡。在单变量模型中,三个基线预测因素(注意力缺陷多动障碍、既往脑震荡和事故倾向)与发生脑震荡显著相关。在多变量模型中,在控制了所有其他预测因素后,只有既往脑震荡在观察期内仍与脑震荡的发生显著相关(优势比 = 5.49,95%置信区间:3.40 - 8.87)。发生脑震荡最有力且唯一的独立前瞻性预测因素是既往脑震荡史。在美国普通人群的儿童中,既往脑震荡史与10至11岁期间发生脑震荡的几率高5.5倍相关。