PhD Science Writer, New York, New York.
European Molecular Biology Laboratory (EMBL), Heidelberg, Heidelberg, Germany.
Ann N Y Acad Sci. 2021 Dec;1506(1):118-141. doi: 10.1111/nyas.14713. Epub 2021 Nov 17.
The human transcriptome contains many types of noncoding RNAs, which rival the number of protein-coding species. From long noncoding RNAs (lncRNAs) that are over 200 nucleotides long to piwi-interacting RNAs (piRNAs) of only 20 nucleotides, noncoding RNAs play important roles in regulating transcription, epigenetic modifications, translation, and cell signaling. Roles for noncoding RNAs in disease mechanisms are also being uncovered, and several species have been identified as potential drug targets. On May 11-14, 2021, the Keystone eSymposium "Noncoding RNAs: Biology and Applications" brought together researchers working in RNA biology, structure, and technologies to accelerate both the understanding of RNA basic biology and the translation of those findings into clinical applications.
人类转录组包含多种类型的非编码 RNA，其数量可与编码蛋白的物种相媲美。从超过 200 个核苷酸的长非编码 RNA（lncRNA）到只有 20 个核苷酸的 piwi 相互作用 RNA（piRNA），非编码 RNA 在调节转录、表观遗传修饰、翻译和细胞信号传导方面发挥着重要作用。非编码 RNA 在疾病机制中的作用也在被揭示，并且已经鉴定出几种作为潜在药物靶点的物种。2021 年 5 月 11 日至 14 日，Keystone 电子研讨会“非编码 RNA：生物学与应用”汇集了从事 RNA 生物学、结构和技术研究的研究人员，以加速对 RNA 基础生物学的理解，并将这些发现转化为临床应用。
