Bonner T I, Affolter H U, Young A C, Young W S
Laboratory of Cell Biology, National Institute of Mental Health, Bethesda, MD 20892.
Brain Res. 1987 Sep;388(3):243-9. doi: 10.1016/0169-328x(87)90031-3.
We have isolated a cDNA clone from a rat cerebral cortex library which encodes the 116 amino acid precursor of the neuropeptide, neurokinin B. The precursor has 68% amino acid homology to the bovine precursor and encodes a single peptide of the tachykinin family. Except for possible small variations at both ends of the message, there appears to be only a single species of neurokinin B mRNA in rat cerebral cortex. In situ hybridization histochemistry indicates that the message is widely distributed in the rat brain in a pattern distinct from that of substance P message.
我们从大鼠大脑皮质文库中分离出一个cDNA克隆，它编码神经肽神经激肽B的116个氨基酸前体。该前体与牛前体有68%的氨基酸同源性，编码速激肽家族的单一肽段。除了信息两端可能存在的微小差异外，大鼠大脑皮质中似乎只有一种神经激肽B mRNA。原位杂交组织化学表明，该信息在大鼠脑中广泛分布，其模式与P物质信息不同。
