The Nursing School, Nanjing Medical University, Nanjing, China.
Jiangyin People's Hospital of Jiangsu Province, Jiangyin, China.
Adv Ther. 2022 Jan;39(1):94-116. doi: 10.1007/s12325-021-01920-6. Epub 2021 Nov 18.
This study aimed to examine the effectiveness of high-intensity interval training (HIIT) on pulmonary function and exercise capacity in individuals with chronic obstructive pulmonary disease (COPD).
Ten databases (PubMed, the Cochrane Library, Web of Science, EMBASE, MEDLINE, CINAHL, CNKI, Wanfang, Weipu, and CBM) were searched for relevant articles published from inception to 30 June 2020. Studies were included if they were randomized controlled trials (RCTs) comparing a HIIT group with usual care or other training groups. Quality was assessed using the Physiotherapy Evidence Database (PEDro) scale, and the overall quality of evidence was assessed using the GRADE approach. The primary outcomes were peak VO and FEV% predicted, and the secondary outcomes were FEV/FVC, peak V, peak WR, 6MWD, dyspnea, health-related quality of life, and adverse event.
Twelve articles (689 patients) were included. HIIT was shown to have a positive effect on exercise capacity (peak WR, 6MWD), pulmonary function (FEV% pred, peak V), dyspnea, and quality of life. However, sensitivity analyses for dyspnea were unstable, and the result changed from positive to negative after removing one study (SMD = - 0.13, 95% CI [- 0.44, 0.17], P = 0.40).
HIIT could improve pulmonary function, exercise capacity, and quality of life but may not decrease dyspnea in patients with COPD. It can be recommended as a safe and effective exercise modality in rehabilitation programs. Given that the overall results were based on a limited number of studies with significant heterogeneity and some of the results were based on low GRADE rating evidence, more high-quality, larger sample size, multicenter, and long-term follow-up RCTs are needed to confirm the clinical efficacy of HIIT in patients with COPD.
CRD42020165897.
本研究旨在探讨高强度间歇训练（HIIT）对慢性阻塞性肺疾病（COPD）患者肺功能和运动能力的影响。
检索了从建库至 2020 年 6 月 30 日的 10 个数据库（PubMed、Cochrane 图书馆、Web of Science、EMBASE、MEDLINE、CINAHL、CNKI、万方、维普和 CBM），以纳入比较 HIIT 组与常规护理或其他训练组的随机对照试验（RCT）。使用物理治疗证据数据库（PEDro）量表评估质量，使用 GRADE 方法评估总体证据质量。主要结局指标为峰值 VO 和 FEV%预计值，次要结局指标为 FEV/FVC、峰值 V、峰值 WR、6MWD、呼吸困难、健康相关生活质量和不良事件。
共纳入 12 篇文章（689 例患者）。HIIT 对运动能力（峰值 WR、6MWD）、肺功能（FEV%预，峰值 V）、呼吸困难和生活质量均有积极影响。然而，呼吸困难的敏感性分析结果不稳定，在去除一项研究后，结果从阳性变为阴性（SMD = -0.13，95%CI[-0.44, 0.17]，P = 0.40）。
HIIT 可改善 COPD 患者的肺功能、运动能力和生活质量，但可能不会降低呼吸困难。它可以作为康复计划中一种安全有效的运动方式。鉴于总体结果基于少数具有显著异质性的研究，并且一些结果基于低 GRADE 评级证据，需要更多高质量、大样本量、多中心和长期随访的 RCT 来证实 HIIT 在 COPD 患者中的临床疗效。
PROSPERO 注册号：CRD42020165897。
