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用于处理伤口的可注射及粘性水凝胶。

Injectable and adhesive hydrogels for dealing with wounds.

作者信息

Ghandforoushan Parisa, Golafshan Nasim, Babu Kadumudi Firoz, Castilho Miguel, Dolatshahi-Pirouz Alireza, Orive Gorka

机构信息

Department of Medicinal Chemistry, Faculty of Pharmacy, Tabriz University of Medical Science, Tabriz, Iran.

Department of Orthopedics, University Medical Center Utrecht, Utrecht, The Netherlands.

出版信息

Expert Opin Biol Ther. 2022 Apr;22(4):519-533. doi: 10.1080/14712598.2022.2008353. Epub 2021 Dec 5.

Abstract

INTRODUCTION

The development of wound dressing materials that combine healing properties, ability to self-repair the material damages, skin-friendly adhesive nature, and competent mechanical properties have surpassing functional importance in healthcare. Due to their specificity, hydrogels have been recognized as a new gateway in biological materials to treat dysfunctional tissues. The design and creation of injectable hydrogel-based scaffolds have extensively progressed in recent years to improve their therapeutic efficacy and to pave the way for their easy minimally invasive administration. Hence, injectable hydrogel biomaterials have been prepared to eventually translate into minimally invasive therapy and pose a lasting effect on regenerative medicine.

AREAS COVERED

This review highlights the recent development of adhesive and injectable hydrogels that have applications in wound healing and wound dressing. Such hydrogel materials are not only expected to improve therapeutic outcomes but also to facilitate the easy surgical process in both wound healing and dressing.

EXPERT OPINION

Wound healing seems to be an appealing approach for treating countless life-threatening disorders. With the average increase of life expectancy in human societies, an increase in demand for injectable skin replacements and drug delivery carriers for chronic wound healing is expected.

摘要

引言

开发兼具愈合特性、自我修复材料损伤能力、亲肤粘性以及良好机械性能的伤口敷料在医疗保健领域具有极其重要的功能意义。由于其特殊性,水凝胶已被视为治疗功能失调组织的生物材料新途径。近年来,基于可注射水凝胶的支架设计与制备取得了长足进展,以提高其治疗效果并为简便的微创给药铺平道路。因此,已制备出可注射水凝胶生物材料,最终转化为微创治疗并对再生医学产生持久影响。

涵盖领域

本综述重点介绍了在伤口愈合和伤口敷料中应用的粘性和可注射水凝胶的最新进展。此类水凝胶材料不仅有望改善治疗效果,还能在伤口愈合和敷料更换过程中简化手术操作。

专家观点

伤口愈合似乎是治疗无数危及生命疾病的一种有吸引力的方法。随着人类社会平均预期寿命的增加,预计对用于慢性伤口愈合的可注射皮肤替代物和药物递送载体的需求也会增加。

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