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BNT162b2 mRNA新冠疫苗接种后发生的脑静脉窦血栓形成

Cerebral Venous Sinus Thrombosis After BNT162b2 mRNA COVID-19 Vaccination.

作者信息

Yamaguchi Yoshitaka, Kimihira Luna, Nagasawa Hikaru, Seo Kyoichi, Wada Manabu

机构信息

Department of Neurology, Yamagata Prefectural Central Hospital, Yamagata, JPN.

Department of Neurosurgery, Yamagata Prefectural Central Hospital, Yamagata, JPN.

出版信息

Cureus. 2021 Oct 14;13(10):e18775. doi: 10.7759/cureus.18775. eCollection 2021 Oct.

DOI:10.7759/cureus.18775
PMID:34796065
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8590453/
Abstract

W present a rare case of cerebral venous sinus thrombosis after the BNT162b2 mRNA COVID-19 vaccine. A 61-year-old Japanese man developed a headache 10 days after the first dose of the vaccine. Magnetic resonance venography and contrast-enhanced brain MRI showed thrombosis in the superior sagittal sinus and the right transverse sinus. Anticoagulation with intravenous unfractionated heparin followed by oral warfarin was started. His headache improved, and brain MRI on day 22 showed resolution of thrombus. He was maintained on anticoagulation with warfarin and discharged without any neurological sequelae. This case is presented in the context of the relevant literature.

摘要

我们报告了1例接种BNT162b2 mRNA新冠疫苗后发生脑静脉窦血栓形成的罕见病例。一名61岁的日本男性在接种第一剂疫苗10天后出现头痛。磁共振静脉造影和对比增强脑MRI显示上矢状窦和右侧横窦血栓形成。开始静脉注射普通肝素抗凝，随后口服华法林。他的头痛有所改善，第22天的脑MRI显示血栓溶解。他继续服用华法林抗凝，出院时无任何神经后遗症。本文结合相关文献对该病例进行介绍。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb39/8590453/e3e0e82bc60b/cureus-0013-00000018775-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb39/8590453/b35a298269b9/cureus-0013-00000018775-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb39/8590453/e3e0e82bc60b/cureus-0013-00000018775-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb39/8590453/b35a298269b9/cureus-0013-00000018775-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb39/8590453/e3e0e82bc60b/cureus-0013-00000018775-i02.jpg

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