Lee Yewon, Yoon Yohan, Choi Kyoung-Hee
Department of Food and Nutrition, Sookmyung Women's University, Seoul 04310, Korea.
Risk Analysis Research Center, Sookmyung Women's University, Seoul 04310, Korea.
Food Sci Anim Resour. 2021 Nov;41(6):905-922. doi: 10.5851/kosfa.2021.e57. Epub 2021 Nov 1.
Novel bioactive metabolites have been developed through a bioconversion of dairy products or other foods using probiotics isolated from dairy products or other fermented foods. These probiotics-mediated bioconversion (PMB) metabolites show antioxidant, anti-inflammatory, antimicrobial, epithelial barrier, and anticancer activities. In addition, the effect of PMB metabolites in periodontitis is recently reported in several studies. Periodontitis is a chronic inflammatory disease caused by infections, and the tooth support tissue is destroyed. Common treatments for periodontitis include scaling and root planning with systemic antibiotics. However, the overuse of antibiotics has led to the emergence of drug-resistant microorganisms and disturbs the beneficial bacteria, including lactobacilli in the oral cavity. For this reason, PMB metabolites, such as fermented milk, have been suggested as substitutes for antibiotics to reduce periodontitis. This paper reviews the recent studies on the correlation between periodontitis and PMB metabolites and classifies the efficacy of major PMB metabolites for periodontitis. The review suggests that PMB is effective for periodontitis, and further studies are needed to confirm the therapeutic effect of PMB metabolites on periodontitis.
通过使用从乳制品或其他发酵食品中分离出的益生菌对乳制品或其他食品进行生物转化，已开发出新型生物活性代谢产物。这些益生菌介导的生物转化（PMB）代谢产物具有抗氧化、抗炎、抗菌、上皮屏障和抗癌活性。此外，最近的几项研究报道了PMB代谢产物在牙周炎中的作用。牙周炎是一种由感染引起的慢性炎症性疾病，牙齿支持组织会遭到破坏。牙周炎的常见治疗方法包括龈下刮治和根面平整以及全身性抗生素治疗。然而，抗生素的过度使用导致了耐药微生物的出现，并扰乱了有益细菌，包括口腔中的乳酸菌。因此，有人建议将PMB代谢产物，如发酵乳，作为抗生素的替代品来减轻牙周炎。本文综述了近期关于牙周炎与PMB代谢产物之间相关性的研究，并对主要PMB代谢产物对牙周炎的疗效进行了分类。该综述表明，PMB对牙周炎有效，还需要进一步研究来证实PMB代谢产物对牙周炎的治疗效果。
