Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
Departments of Chemistry and Biological Chemistry, University of Michigan, Ann Arbor, MI, USA.
EMBO Rep. 2022 Jan 5;23(1):e54258. doi: 10.15252/embr.202154258. Epub 2021 Nov 19.
What to eat when you have a cold has always been the subject of much debate and advice, usually informed by very little science. However, in this issue of EMBO Reports, Yuan et al (2021) uncover an intriguing link between a high salt diet and a susceptibility to viral infection. Mice fed on a short-term high salt diet were found to carry a higher viral load than control mice fed a normal diet. The researchers trace this effect back to a salt-induced decrease in cellular levels of the antiviral protein, viperin. More generally, these studies provide further insights into the regulation of proteins involved in the cellular antiviral response.
当人们感冒时，应该吃什么一直是一个备受争议和有各种建议的话题，而这些建议通常很少基于科学依据。然而，在本期的《EMBO 报告》中，袁等人（2021 年）揭示了高盐饮食与易感染病毒之间的一个有趣的联系。研究人员发现，短期高盐饮食的小鼠比正常饮食的对照小鼠携带更高的病毒载量。研究人员将这种效应追溯到盐诱导的抗病毒蛋白 viperin 细胞水平下降。更普遍的是，这些研究为细胞抗病毒反应中涉及的蛋白质的调控提供了进一步的见解。
